L
Lorenz Trümper
Researcher at University of Göttingen
Publications - 276
Citations - 22696
Lorenz Trümper is an academic researcher from University of Göttingen. The author has contributed to research in topics: Lymphoma & Diffuse large B-cell lymphoma. The author has an hindex of 53, co-authored 260 publications receiving 19534 citations. Previous affiliations of Lorenz Trümper include Deutsche Forschungsgemeinschaft & University of Cologne.
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Journal ArticleDOI
Circulating Levels of TNF Receptor II Are Prognostic for Patients with Peripheral T-cell Non–Hodgkin Lymphoma
Christina Heemann,Markus Kreuz,Irene Stoller,Nils Schoof,Frederike von Bonin,Marita Ziepert,Markus W. Löffler,Wolfram Jung,Michael Pfreundschuh,Lorenz Trümper,Dieter Kube +10 more
TL;DR: A critical role is suggested for TNF-TNFR signaling for the clinical outcome of patients with peripheral T-NHLs and Elevations of circulating levels of sTNFRI, IL-10, and sIL-4R are frequent, but the clinical response in these patients is not significantly different.
Journal ArticleDOI
High resolution copy number analysis of IRF4 translocation-positive diffuse large B-cell and follicular lymphomas
Itziar Salaverria,Idoia Martin-Guerrero,Idoia Martin-Guerrero,Birgit Burkhardt,Markus Kreuz,Thorsten Zenz,Thorsten Zenz,Ilske Oschlies,Norbert Arnold,Michael Baudis,Susanne Bens,Africa Garcia-Orad,Jasmin Lisfeld,Carsten Schwaenen,Monika Szczepanowski,Swen Wessendorf,Michael Pfreundschuh,Lorenz Trümper,Wolfram Klapper,Reiner Siebert +19 more
TL;DR: A recurrent pattern of secondary genetic alterations in IRF4 translocation‐positive lymphomas is unraveled, finding no recurrent copy‐neutral losses of heterozygosity.
Journal ArticleDOI
Reduced-intensity conditioning prior to allogeneic transplantation of hematopoietic stem cells: the need for T cells early after transplantation to induce a graft-versus-lymphoma effect
B. Glass,Maike Nickelsen,Peter Dreger,Alexander Claviez,Justin Hasenkamp,Gerald Wulf,Lorenz Trümper,Norbert Schmitz +7 more
TL;DR: In this paper, the authors tried to address the problem by intermediate-intensity conditioning followed by allogeneic SCT in patients with poor-risk relapse of aggressive lymphoma, which may have its limitations because of rapid regrowth of the tumor.
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The PCBP1 gene encoding poly(rC) binding protein I is recurrently mutated in Burkitt lymphoma.
Rabea Wagener,Sietse M. Aukema,Matthias Schlesner,Andrea Haake,Birgit Burkhardt,Alexander Claviez,Hans G. Drexler,Michael Hummel,Markus Kreuz,Markus Loeffler,Maciej Rosolowski,Cristina López,Peter Møller,Julia Richter,Marius Rohde,Matthew J. Betts,Robert B. Russell,Stephan H. Bernhart,Steve Hoffmann,Philip Rosenstiel,Markus Schilhabel,Monika Szczepanowski,Lorenz Trümper,Wolfram Klapper,Reiner Siebert,Icgc MMML-Seq-Project +25 more
TL;DR: It is shown that PCBP1 mutations are recurrent in Burkitt lymphomas and might contribute, in cooperation with other mutations, to its pathogenesis.
Journal ArticleDOI
Paraproteins of familial MGUS/multiple myeloma target family-typical antigens: hyperphosphorylation of autoantigens is a consistent finding in familial and sporadic MGUS/MM
Sandra Grass,Klaus Dieter Preuss,Stephan D. Thomé,Dennis D. Weisenburger,Vinetta Witt,Jane F. Lynch,Florian Zettl,Lorenz Trümper,Natalie Fadle,Evi Regitz,Henry T. Lynch,Michael Pfreundschuh +11 more
TL;DR: Paratarg-7 (P-7) is a frequent paraprotein target in monoclonal gammopathy of undetermined significance (MGUS), multiple myeloma (MM), and Waldenström macroglobulinemia and hyperphosphorylation of paraprotein targets might be a general mechanism underlying the pathogenesis of MGUS/MM.