L
Lorenz Trümper
Researcher at University of Göttingen
Publications - 276
Citations - 22696
Lorenz Trümper is an academic researcher from University of Göttingen. The author has contributed to research in topics: Lymphoma & Diffuse large B-cell lymphoma. The author has an hindex of 53, co-authored 260 publications receiving 19534 citations. Previous affiliations of Lorenz Trümper include Deutsche Forschungsgemeinschaft & University of Cologne.
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Journal ArticleDOI
Lenalidomide versus investigator's choice in relapsed or refractory mantle cell lymphoma (MCL-002; SPRINT): a phase 2, randomised, multicentre trial
Marek Trněný,Thierry Lamy,Jan Walewski,David Belada,Jiri Mayer,John Radford,Wojciech Jurczak,Franck Morschhauser,Julia Alexeeva,Simon Rule,Boris V. Afanasyev,K. D. Kaplanov,Antoine Thyss,Alexej Kuzmin,Sergey Voloshin,Kazimierz Kuliczkowski,Agnieszka Giza,Noel Milpied,Caterina Stelitano,Reinhard Marks,Lorenz Trümper,Tsvetan Biyukov,Meera Patturajan,Marie Laure Casadebaig Bravo,Luca Arcaini +24 more
TL;DR: Patients with relapsed or refractory mantle cell lymphoma ineligible for intensive chemotherapy or stem-cell transplantation have longer progression-free survival, with a manageable safety profile when treated with lenalidomide compared with monotherapy investigator's choice options.
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Molecular profiling of pediatric mature B-cell lymphoma treated in population-based prospective clinical trials
Wolfram Klapper,Monika Szczepanowski,Birgit Burkhardt,Birgit Burkhardt,Hilmar Berger,Maciej Rosolowski,Stefan Bentink,Carsten Schwaenen,Swen Wessendorf,Rainer Spang,Peter Møller,Martin-Leo Hansmann,Heinz-Wolfram Bernd,German Ott,German Ott,Michael Hummel,Harald Stein,Markus Loeffler,Lorenz Trümper,Martin Zimmermann,Martin Zimmermann,Alfred Reiter,Reiner Siebert +22 more
TL;DR: First report on molecular profiling of pediatric B-NHL showing mBL to be much more prominent in children than suggested by morphologic assessment and a molecularly homogeneous disease across children and adults.
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DNA methylome analysis in Burkitt and follicular lymphomas identifies differentially methylated regions linked to somatic mutation and transcriptional control
Helene Kretzmer,Stephan H. Bernhart,Wei Wang,Andrea Haake,Marc A. Weniger,Anke K. Bergmann,Matthew J. Betts,Enrique Carrillo-de-Santa-Pau,Gero Doose,Jana Gutwein,Julia Richter,Volker Hovestadt,Bingding Huang,Daniel Rico,Frank Jühling,Julia Kolarova,Qianhao Lu,Christian Otto,Rabea Wagener,Judith Arnolds,Birgit Burkhardt,Alexander Claviez,HG Drexler,Sonja Eberth,Sonja Eberth,Roland Eils,Roland Eils,Paul Flicek,Siegfried Haas,Michael Hummel,Dennis Karsch,Hinrik H.D. Kerstens,Wolfram Klapper,Markus Kreuz,Chris Lawerenz,Dido Lenze,Markus Loeffler,Cristina López,Roderick A. F. MacLeod,Joost H.A. Martens,Marta Kulis,José I. Martín-Subero,Peter Möller,Inga Nagel,Simone Picelli,Inga Vater,Marius Rohde,Philip Rosenstiel,Maciej Rosolowski,Robert B. Russell,Markus Schilhabel,Matthias Schlesner,Peter F. Stadler,Monika Szczepanowski,Lorenz Trümper,Hendrik G. Stunnenberg,Ralf Küppers,Ole Ammerpohl,Peter Lichter,Reiner Siebert,Steve Hoffmann,Bernhard Radlwimmer +61 more
TL;DR: The results demonstrate a tight connection between somatic mutation, DNA methylation and transcriptional control in key B cell pathways deregulated differentially in Burkitt lymphoma and other germinal center B cell lymphomas.
Journal ArticleDOI
Mesengenic progenitor cells derived from human placenta.
Gerald Wulf,Volker Viereck,Bernhard Hemmerlein,Detlef Haase,Katalin Vehmeyer,Tobias Pukrop,Bertram Glass,Günter Emons,Lorenz Trümper +8 more
TL;DR: Human term placenta is proposed as an easily accessible, ample source of multipotent mesengenic progenitor cells and differentiation experiments showed differentiation potential along osteogenic, chondrogenic, adipogenic, and myogenic lineages.
Journal ArticleDOI
High Rates of Durable Responses With Anti-CD22 Fractionated Radioimmunotherapy: Results of a Multicenter, Phase I/II Study in Non-Hodgkin's Lymphoma
Franck Morschhauser,Françoise Kraeber-Bodéré,William A. Wegener,Jean-Luc Harousseau,Marie-Odile Petillon,Damien Huglo,Lorenz Trümper,Johannes Meller,Michael Pfreundschuh,Carl-Martin Kirsch,Ralph Naumann,Joachim Kropp,Heather Horne,Nick Teoh,Steven Le Gouill,Caroline Bodet-Milin,Jean-François Chatal,David M. Goldenberg +17 more
TL;DR: Fractionated anti-CD22 radioimmunotherapy provides high total doses of (90)Y, yielding high rates of durable CR/CRus in relapsed/refractory NHL, resulting in 20 mCi/m(2) x 2 weeks as the recommended dose for future studies.