L
Lorenz Trümper
Researcher at University of Göttingen
Publications - 276
Citations - 22696
Lorenz Trümper is an academic researcher from University of Göttingen. The author has contributed to research in topics: Lymphoma & Diffuse large B-cell lymphoma. The author has an hindex of 53, co-authored 260 publications receiving 19534 citations. Previous affiliations of Lorenz Trümper include Deutsche Forschungsgemeinschaft & University of Cologne.
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Journal ArticleDOI
Signal transducer and activator of transcription 6 is frequently activated in Hodgkin and Reed-Sternberg cells of Hodgkin lymphoma
Brian F. Skinnider,Andrew J. Elia,Randy D. Gascoyne,Bruce K. Patterson,Lorenz Trümper,Ursula Kapp,Tak W. Mak +6 more
TL;DR: Immunoblotting and immunohistochemistry results suggest that IL-13 signaling is largely responsible for the constitutive STAT6 activation observed in HRS cells and further implicate IL- 13 as an important growth factor in classical HL.
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Exosomal evasion of humoral immunotherapy in aggressive B-cell lymphoma modulated by ATP-binding cassette transporter A3
Thiha Aung,Bjoern Chapuy,Bjoern Chapuy,Daniel Vogel,Dirk Wenzel,Martin Oppermann,Marlen Lahmann,Toni Weinhage,Kerstin Menck,Timo Hupfeld,Raphael Koch,Lorenz Trümper,Gerald Wulf +12 more
TL;DR: It is shown that lymphoma exosomes shield target cells from antibody attack and that exosome biogenesis is modulated by the lysosome-related organelle-associated ATP-binding cassette (ABC) transporter A3 (ABCA3), and mechanisms of cancer cell resistance to drugs and antibodies are linked in an ABCA3-dependent pathway of exosomal secretion.
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Classical Hodgkin lymphoma is characterized by recurrent copy number gains of the short arm of chromosome 2.
Stefan Joos,Christiane K. Menz,Gunnar Wrobel,Reiner Siebert,Stefan Gesk,Sibylle Ohl,Gunhild Mechtersheimer,Lorenz Trümper,Peter Møller,Peter Lichter,Thomas F. E. Barth +10 more
TL;DR: The imbalance pattern of cHL subtypes suggests that different molecular pathways are activated, with REL or other genes on chromosomal band 2p15-p16 playing a fundamental role in the pathogenesis of classical Hodgkin lymphoma.
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Combined analysis of ZAP-70 and CD38 expression as a predictor of disease progression in B-cell chronic lymphocytic leukemia.
Roland Schroers,Frank Griesinger,Lorenz Trümper,Detlef Haase,B Kulle,Ludger Klein-Hitpass,Ludger Sellmann,Ulrich Dührsen,Jan Dürig +8 more
TL;DR: Over-representation of high-risk genomic aberrations such as 17p deletion or 11q deletion and distribution of the IgVH mutation status in B-CLL discordant for ZAP-70/CD38 pointed toward a distinct biologic background of the observed disease subgroups.
Journal ArticleDOI
Interleukin 13 and interleukin 13 receptor are frequently expressed by Hodgkin and Reed-Sternberg cells of Hodgkin lymphoma.
Brian Skinnider,Andrew J. Elia,Randy D. Gascoyne,Lorenz Trümper,Frederike von Bonin,Ursula Kapp,Bruce K. Patterson,Bryan E. Snow,Tak W. Mak +8 more
TL;DR: Exposure to in situ hybridization of interleukin-13 and IL-13Ralpha1 is a common feature of HRS cells in HL, consistent with the hypothesis that IL- 13 may play a role in autocrine growth in classical HL.