L
Lorenz Trümper
Researcher at University of Göttingen
Publications - 276
Citations - 22696
Lorenz Trümper is an academic researcher from University of Göttingen. The author has contributed to research in topics: Lymphoma & Diffuse large B-cell lymphoma. The author has an hindex of 53, co-authored 260 publications receiving 19534 citations. Previous affiliations of Lorenz Trümper include Deutsche Forschungsgemeinschaft & University of Cologne.
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The ECHELON-2 Trial: Results of a Randomized, Double-Blind, Active-Controlled Phase 3 Study of Brentuximab Vedotin and CHP (A+CHP) Versus CHOP in the Frontline Treatment of Patients with CD30+ Peripheral T-Cell Lymphomas
Steven M. Horwitz,Owen A. O'Connor,Barbara Pro,Timothy M Illidge,Michelle A. Fanale,Ranjana H. Advani,Nancy L. Bartlett,Jacob Haaber Christensen,Franck Morschhauser,Eva Domingo-Domenech,Giuseppe Rossi,Won Seog Kim,Tatyana Feldman,Anne Lennard,David Belada,Árpád Illés,Kensei Tobinai,Kunihiro Tsukasaki,Su-Peng Yeh,Andrei R. Shustov,Andreas Hüttmann,Kerry J. Savage,Sam Yuen,Pier Luigi Zinzani,Zhaowei Hua,Meredith Little,Shangbang Rao,Joseph Woolery,Thomas Manley,Lorenz Trümper +29 more
TL;DR: The blinded, pooled analyses per investigator of the ECHELON-2 trial, a phase 3, randomized, double-blind, active-controlled, multicenter study to compare the efficacy and safety of brentuximab vedotin in combination with CHP (A+CHP) versus standard CHOP for the treatment of patients with PTCL, reported on.
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CD34+ FISH As a New Method for Molecular-Cytogenetic Diagnostic From Peripheral Blood in MDS: Update of the Multicenter German Prospective Diagnostic Study
Friederike Braulke,Julie Schanz,Katharina Götze,Catharina Müller-Thomas,Uwe Platzbecker,Christina Ganster,Klaus Jung,Michael Metz,Sven Detken,Jörg Seraphin,Tim H. Brümmendorf,Aristoteles Giagounidis,Ulrich Germing,Kathleen Jentsch-Ullrich,Angelika Böhme,Gesine Bug,Oliver G. Ottmann,Philippe Schafhausen,Michael Stadler,Wolf-Karsten Hofmann,Burkhard Schmidt,Michael Lübbert,Richard F. Schlenk,Igor Wolfgang Blau,Lorenz Trümper,Detlef Haase +25 more
TL;DR: FISH analysis of circulating CD34+ pb cells provides relevant cytogenetic informations in patients with MDS during the course of disease and under different therapies, and helps in cases where a bm biopsy is not possible or not successful.
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Significant Suppression of the Colony Forming Capacity of Erythroid Progenitors by Iron Overload in Patients with MDS and Sequential Anlyses of BFU-E Under Chelation Therapy.
Julia Hartmann,Ursula Sinzig,Gerald Wulf,Lorenz Trümper,Frank Konietschke,Stephanie Fischer,Detlef Haase +6 more
TL;DR: Iron overload might not only be harmful to hepatocytes and cardiomyocytes but also to bone marrow progenitor cells and might be further affected by a “second hit” in the form of toxic iron overload which might additionally impair their colony forming capacity.
Journal ArticleDOI
STAT3 is essential for Hodgkin lymphoma cell proliferation and is a target of tyrphostin AG17 which confers sensitization for apoptosis
Dieter Kube,Nils Schoof,Diana Pinkert,Kathrin Matthias,Michaela Schröder,Jobst Landgrebe,Peter Brechlin,Markus Otto,Lorenz Trümper +8 more
Journal ArticleDOI
Modified BEAM with triple autologous stem cell transplantation for patients with relapsed aggressive non-Hodgkin lymphoma
Karin Hohloch,Samira Zeynalova,Björn Chapuy,Björn Chapuy,Michael Pfreundschuh,Markus Loeffler,Marita Ziepert,Alfred C. Feller,Lorenz Trümper,Dirk Hasenclever,Gerald Wulf,Norbert Schmitz +11 more
TL;DR: Dose escalation of standard BEAM is not feasible due to toxicity, and patients with relapsed aggressive non-Hodgkin lymphoma responded to DexaBEAM with a sufficient stem cell harvest.