The Intestinal Microbiota Contributes to the Ability of Helminths to Modulate Allergic Inflammation
Mario M. Zaiss,Alexis Rapin,Luc Lebon,Lalit Kumar Dubey,Ilaria Mosconi,Kerstin Sarter,Alessandra Piersigilli,Alessandra Piersigilli,Laure Menin,Alan W. Walker,Alan W. Walker,Jacques Rougemont,Oonagh Paerewijck,Peter Geldhof,Kathleen McCoy,Andrew J. Macpherson,John Croese,Paul R. Giacomin,Alex Loukas,Tobias Junt,Benjamin J. Marsland,Nicola L. Harris +21 more
TLDR
Chronic infection with the murine helminth Heligmosomoides polygyrus bakeri altered the intestinal habitat, allowing increased short chain fatty acid (SCFA) production and a similar alteration in the metabolic potential of intestinal bacterial communities was observed with diverse parasitic and host species, suggesting that this represents an evolutionary conserved mechanism of host-microbe-helminth interactions.About:
This article is published in Immunity.The article was published on 2015-11-17 and is currently open access. It has received 331 citations till now. The article focuses on the topics: Intestinal mucosa & Allergic inflammation.read more
Citations
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From Dietary Fiber to Host Physiology: Short-Chain Fatty Acids as Key Bacterial Metabolites
TL;DR: Data is reviewed supporting the diverse functional roles carried out by a major class of bacterial metabolites, the short-chain fatty acids (SCFAs), which affect various physiological processes and may contribute to health and disease.
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Emerging pathogenic links between microbiota and the gut-lung axis
Kurtis F. Budden,Shaan L. Gellatly,David L. A. Wood,Mark E. Cooper,Mark Morrison,Philip Hugenholtz,Philip M. Hansbro +6 more
TL;DR: Although the gut–lung axis is only beginning to be understood, emerging evidence indicates that there is potential for manipulation of the gut microbiota in the treatment of lung diseases.
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You are what you eat: diet, health and the gut microbiota.
TL;DR: The major principles underlying effects of dietary constituents on the gut microbiota are reviewed, resolving aspects of the diet–microbiota–host crosstalk, and the promises and challenges of incorporating microbiome data into dietary planning are presented.
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Free Fatty Acid Receptors in Health and Disease.
TL;DR: Recent reports on the key physiological functions of the FFAR-mediated signaling transduction pathways in the regulation of metabolism and immune responses are discussed and future research opportunities for developing therapeutics for metabolic and immune disorders are revealed.
Journal ArticleDOI
Regulation of the host immune system by helminth parasites
TL;DR: The panoply of immunomodulatory mechanisms used by helminths, their potential utility in human disease, and prospective areas of future research are summarized.
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