M
Madeleine Le Coz
Researcher at Curie Institute
Publications - 4
Citations - 799
Madeleine Le Coz is an academic researcher from Curie Institute. The author has contributed to research in topics: Microphthalmia-associated transcription factor & Cilium. The author has an hindex of 3, co-authored 4 publications receiving 740 citations. Previous affiliations of Madeleine Le Coz include Université Paris-Saclay & Fox Chase Cancer Center.
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Journal ArticleDOI
Thymine DNA glycosylase is essential for active DNA demethylation by linked deamination-base excision repair.
Salvatore Cortellino,Jinfei Xu,Mara Sannai,Robert Moore,Elena Caretti,Antonio Cigliano,Madeleine Le Coz,Karthik Devarajan,Andy Wessels,Dianne Robert Soprano,Lara K. Abramowitz,Marisa S. Bartolomei,Florian Rambow,Florian Rambow,Maria Rosaria Bassi,Tiziana Bruno,Maurizio Fanciulli,Catherine Renner,Andres J. Klein-Szanto,Yoshihiro Matsumoto,Dominique Kobi,Irwin Davidson,Christophe Alberti,Christophe Alberti,Lionel Larue,Lionel Larue,Alfonso Bellacosa +26 more
TL;DR: It is shown that either knockout or catalytic inactivation of the DNA repair enzyme thymine DNA glycosylase (TDG) leads to embryonic lethality in mice, and a dual role for TDG in promoting proper epigenetic states during development is highlighted, suggesting a two-step mechanism for DNA demethylation in mammals.
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Chromatin-Remodelling Complex NURF Is Essential for Differentiation of Adult Melanocyte Stem Cells
Dana Koludrovic,Patrick Laurette,Thomas Strub,Céline Keime,Madeleine Le Coz,Sebastien Coassolo,Gabrielle Mengus,Lionel Larue,Irwin Davidson +8 more
TL;DR: It is shown that MITF associates the NURF chromatin-remodelling factor in melanoma cells and shRNA-mediated silencing of the NurF subunit BPTF revealed its essential role in several melanoma cell lines and in untransformed melanocytes in vitro.
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BRN2 is a non-canonical melanoma tumor-suppressor.
Michael Hamm,Michael Hamm,Pierre Sohier,Pierre Sohier,Valérie Petit,Valérie Petit,Jérémy H. Raymond,Jérémy H. Raymond,Véronique Delmas,Véronique Delmas,Madeleine Le Coz,Madeleine Le Coz,Franck Gesbert,Franck Gesbert,Colin Kenny,Zackie Aktary,Zackie Aktary,Marie Pouteaux,Marie Pouteaux,Florian Rambow,Florian Rambow,Alain Sarasin,Nisamanee Charoenchon,Alfonso Bellacosa,Luis Sánchez-del-Campo,Laura Mosteo,Martin Lauss,Dies Meijer,Eiríkur Steingrímsson,Göran Jönsson,Robert A. Cornell,Irwin Davidson,Irwin Davidson,Colin R. Goding,Lionel Larue,Lionel Larue +35 more
TL;DR: In this paper, the role of BRN2 in melanoma initiation and metastasis was investigated in a BrafV600E PtenF/+ context, and it was shown that deletion of one allele and temporal regulation of the other allele elicits melanoma induction and progression.
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Quiescent melanocytes form primary cilia.
TL;DR: It is shown, for the first time, that melanocytes can form a primary cilium in vitro, corresponding to an immotile or sensory cilial corresponding to the signal transduction processes potentially occurring in these cells during embryonic development, homeostasis in adulthood and melanomagenesis.