M
Magnus von Knebel-Doeberitz
Researcher at Heidelberg University
Publications - 22
Citations - 1120
Magnus von Knebel-Doeberitz is an academic researcher from Heidelberg University. The author has contributed to research in topics: Microsatellite instability & Cancer. The author has an hindex of 14, co-authored 22 publications receiving 1021 citations. Previous affiliations of Magnus von Knebel-Doeberitz include Hoffmann-La Roche & University Hospital Heidelberg.
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Journal ArticleDOI
HNPCC-associated small bowel cancer: Clinical and molecular characteristics
Karsten Schulmann,Frank Brasch,Erdmute Kunstmann,Christoph Engel,Constanze Pagenstecher,Holger Vogelsang,Stefan Krüger,T. Vogel,Hanns Peter Knaebel,Josef Rüschoff,Stephan A. Hahn,Magnus von Knebel-Doeberitz,Gabriela Moeslein,Stephen J. Meltzer,Hans K. Schackert,Christiane Tympner,Elisabeth Mangold,Wolff Schmiegel +17 more
TL;DR: This study proposes endoscopic screening of mutation carriers starting at 30 years of age because clinical criteria cannot define a high-risk group and shows that histopathologic criteria, microsatellite instability, MSI, and MMR immunohistochemistry are often similar to these features in HNPCC.
Journal Article
Microsatellite instability analysis: a multicenter study for reliability and quality control
Tina Bocker,Johannes Diermann,Waltraut Friedl,Johannes Gebert,Elke Holinski-Feder,Judith Karner-Hanusch,Magnus von Knebel-Doeberitz,Konrad Koelble,Gabriela Moeslein,H. K. Schackert,Hans Christian Wirtz,Richard Fishel,Josef Rüschoff +12 more
TL;DR: It is proposed that a panel of five microsatellite loci consisting of repeats with different lengths should be analyzed in an initial analysis, and when less than two marker loci display shifts in the micros satellite bands from tumor DNA, the panel should be enlarged to include an additional set of five marker Loci.
Journal ArticleDOI
Further evidence for heritability of an epimutation in one of 12 cases with MLH1 promoter methylation in blood cells clinically displaying HNPCC
Monika Morak,Hans K. Schackert,Nils Rahner,Beate Betz,Matthias P.A. Ebert,Constanze Walldorf,Brigitte Royer-Pokora,Karsten Schulmann,Magnus von Knebel-Doeberitz,Wolfgang Dietmaier,Gisela Keller,Brigitte Kerker,Gertraud Leitner,Elke Holinski-Feder +13 more
TL;DR: Findings provide strong evidence that MLH 1 promoter methylation in normal body cells mimics HNPCC and constitutes a pathogenic pre-lesion in MLH1.
Journal ArticleDOI
Worldwide genomic diversity of the high-risk human papillomavirus types 31, 35, 52, and 58, four close relatives of human papillomavirus type 16
Itzel E. Calleja-Macias,Luisa L. Villa,Jose C. Prado,Mina Kalantari,Bruce Allan,Anna-Lise Williamson,Lap Ping Chung,R. J. Collins,Rosemary E. Zuna,S. Terence Dunn,Tang Yuan Chu,Heather A. Cubie,Kate Cuschieri,Magnus von Knebel-Doeberitz,Cláudia R. F. Martins,Gloria I. Sanchez,F. Xavier Bosch,Nubia Muñoz,Hans-Ulrich Bernard,Hans-Ulrich Bernard +19 more
TL;DR: This study addresses the question of whether geography and ethnicity also correlate with sequence variations found for HPV-31, -35, -52, and -58 by sequencing the long control region in samples derived from Europe, Asia, and Africa, and from immigrant populations in North and South America.
Journal ArticleDOI
No role for human papillomavirus in esophageal squamous cell carcinoma in China
Jill Koshiol,Wen Qiang Wei,Aimée R. Kreimer,Wen Chen,Patti E. Gravitt,Jian Song Ren,Christian C. Abnet,Jianbing Wang,Farin Kamangar,Farin Kamangar,Dong Mei Lin,Magnus von Knebel-Doeberitz,Yu Zhang,Raphael P. Viscidi,Guo-Qing Wang,Maura L. Gillison,Maura L. Gillison,Mark J. Roth,Zhi Wei Dong,Esther Kim,Esther Kim,Philip R. Taylor,You-Lin Qiao,Sanford M. Dawsey +23 more
TL;DR: This study provides the most definitive evidence to date that HPV is not involved in ESCC carcinogenesis in China and DNA contamination cannot be ruled out as an explanation for high HPV prevalence in ES CC tissue studies with less stringent tissue procurement and processing protocols.