Maria João Silva

TL;DR: In this article, an inter-laboratory slide-scoring exercise was performed among 34 laboratories from 21 countries with a total of 51 slide scorers involved, and the results of these studies indicate clearly that even after standardizing culture and scoring conditions it will be necessary to calibrate scorers and laboratories if MN, MNed cell and nucleoplasmic bridge frequencies are reliably compared among laboratories and among populations.

TL;DR: Several HTS/HCA methods are being validated and applied for NM testing in the FP7 project NANoREG, including Label‐free cellular screening of NM uptake, HTS, HCA, High throughput flow cytometry, Impedance‐based monitoring, Multiplex analysis of secreted products, and genotoxicity methods.

TL;DR: In the proposed risk assessment strategy, approaches for (Quantitative) Structure Activity Relationships, grouping and read-across are integrated and expanded to guide the user how to prioritise those nanomaterial applications that may lead to high risks for human health.

TL;DR: The differential genotoxicity observed for closely related NMs highlights the importance of investigating the toxic potential of each NM individually, instead of assuming a common mechanism and equal genotoxic effects for a set of similar NMs.

TL;DR: The state-of-the-art of HBM use in chemicals RA with a special focus in Europe is reviewed, the availability of guidance on how to use it in RA is analyzed, and attempts to identify hurdles and challenges faced by regulators are identified.