M
Martin Pelletier
Researcher at Laval University
Publications - 68
Citations - 4409
Martin Pelletier is an academic researcher from Laval University. The author has contributed to research in topics: Cytokine & Proinflammatory cytokine. The author has an hindex of 28, co-authored 64 publications receiving 3469 citations. Previous affiliations of Martin Pelletier include University of Verona & Institut national de la recherche scientifique.
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Journal ArticleDOI
Mitochondrial reactive oxygen species promote production of proinflammatory cytokines and are elevated in TNFR1-associated periodic syndrome (TRAPS)
Ariel C. Bulua,Anna Simon,Ravikanth Maddipati,Martin Pelletier,Heiyoung Park,Kye Young Kim,Michael N. Sack,Daniel L. Kastner,Richard M. Siegel +8 more
TL;DR: ROS generated by mitochondrial respiration are needed for optimal proinflammatory cytokine production in healthy cells, and are elevated in cells from patients with an autoinflammatory disorder.
Journal ArticleDOI
Evidence for a cross-talk between human neutrophils and Th17 cells
Martin Pelletier,Laura Maggi,Alessandra Micheletti,Elena Lazzeri,Nicola Tamassia,Claudio Costantini,Lorenzo Cosmi,Claudio Lunardi,Francesco Annunziato,Sergio Romagnani,Marco A. Cassatella +10 more
TL;DR: A novel chemokine-dependent reciprocal cross-talk between neutrophils and Th17 cells is revealed, which may represent a useful target for the treatment of chronic inflammatory diseases.
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Additive loss-of-function proteasome subunit mutations in CANDLE/PRAAS patients promote type I IFN production
Anja Brehm,Yin Liu,Afzal Sheikh,Bernadette Marrero,Ebun Omoyinmi,Qing Zhou,G Montealegre,Angelique Biancotto,Adam L Reinhardt,Adriana Almeida de Jesus,Martin Pelletier,Wanxia L. Tsai,Elaine F. Remmers,Lela Kardava,Suvimol Hill,Hanna Kim,Helen J. Lachmann,André Mégarbané,Jae Jin Chae,Jilian Brady,Rhina D. Castillo,Diane E. Brown,Angel Vera Casano,Ling Gao,Dawn Chapelle,Yan Huang,Deborah L. Stone,Yongqing Chen,Franziska Sotzny,Chyi-Chia Richard Lee,Daniel L. Kastner,Antonio Torrelo,Abraham Zlotogorski,Susan Moir,Massimo Gadina,Phil McCoy,Robert Wesley,Kristina I. Rother,Peter W. Hildebrand,Paul A. Brogan,Elke Krüger,Ivona Aksentijevich,Raphaela Goldbach-Mansky +42 more
TL;DR: Function evaluation revealed that these mutations variably affect transcription, protein expression, protein folding, proteasome assembly, and, ultimately, proteAsome activity, and defects in proteasomesome formation and function were recapitulated by siRNA-mediated knockdown of the respective subunits in primary fibroblasts from healthy individuals.
Journal ArticleDOI
Colchicine for community-treated patients with COVID-19 (COLCORONA): a phase 3, randomised, double-blinded, adaptive, placebo-controlled, multicentre trial.
Jean-Claude Tardif,Nadia Bouabdallaoui,Philippe L. L’Allier,Daniel Gaudet,Binita Shah,Michael H. Pillinger,Jose Lopez-Sendon,Protasio da Luz,Lucie Verret,Sylvia Audet,Jocelyn Dupuis,André Y. Denault,Martin Pelletier,Philippe A. Tessier,Sarah Samson,Denis Fortin,J.C. Tardif,David Busseuil,Elisabeth Goulet,Chantal Lacoste,Anick Dubois,Avni Y. Joshi,David D. Waters,Priscilla Y. Hsue,Norman E. Lepor,Frédéric Lesage,Nicolas Sainturet,Eve Roy-Clavel,Zohar Bassevitch,Andreas Orfanos,Gabriela Stamatescu,Jean Grégoire,Lambert Busque,Christian Lavallée,Pierre-Olivier Hétu,Jean-Sébastien Paquette,Spyridon Deftereos,Sylvie Levesque,Mariève Cossette,Anna Nozza,Malorie Chabot-Blanchet,Marie-Pierre Dubé,Marie-Claude Guertin,Guy Boivin +43 more
TL;DR: The COLCORONA trial as mentioned in this paper investigated the effect of colchicine on the composite of COVID-19-related death or hospital admission and found that colchics led to a lower rate of the composite adverse events than placebo.
Journal ArticleDOI
Toll‐Like Receptor‐3‐Activated Human Mesenchymal Stromal Cells Significantly Prolong the Survival and Function of Neutrophils
Marco A. Cassatella,Federico Mosna,Alessandra Micheletti,Veronica Lisi,Nicola Tamassia,Caterina Cont,Federica Calzetti,Martin Pelletier,Giovanni Pizzolo,Mauro Krampera +9 more
TL;DR: It is shown that TLR3 triggering by polyinosinic:polycytidylic acid dramatically amplifies, in a more significant manner than TLR4 triggering by lipopolysaccharide, the antiapoptotic effects that resting BM‐MSC constitutively exert on PMN under coculture conditions, preserving a significant fraction of viable and functional PMN up to 72 hours.