J
Javier Prado-Martinez
Researcher at Wellcome Trust Sanger Institute
Publications - 26
Citations - 3781
Javier Prado-Martinez is an academic researcher from Wellcome Trust Sanger Institute. The author has contributed to research in topics: Population & Gene. The author has an hindex of 18, co-authored 25 publications receiving 3203 citations. Previous affiliations of Javier Prado-Martinez include Barcelona Biomedical Research Park & Spanish National Research Council.
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Journal ArticleDOI
Great ape genetic diversity and population history
Javier Prado-Martinez,Peter H. Sudmant,Jeffrey M. Kidd,Jeffrey M. Kidd,Heng Li,Joanna L. Kelley,Belen Lorente-Galdos,Krishna R. Veeramah,August E. Woerner,Timothy D. O’Connor,Gabriel Santpere,Alex Cagan,Christoph Theunert,Ferran Casals,Hafid Laayouni,Kasper Munch,Asger Hobolth,Anders E. Halager,Maika Malig,Jessica Hernandez-Rodriguez,Irene Hernando-Herraez,Kay Prüfer,Marc Pybus,Laurel Johnstone,Michael Lachmann,Can Alkan,Dorina Twigg,Natalia Petit,Carl Baker,Fereydoun Hormozdiari,Marcos Fernandez-Callejo,Marc Dabad,Michael L. Wilson,Laurie S. Stevison,Cristina Camprubí,Tiago Carvalho,Aurora Ruiz-Herrera,Laura Vives,Marta Melé,Teresa Abello,Ivanela Kondova,Ronald E. Bontrop,Anne E. Pusey,Felix Lankester,John Kiyang,Richard A. Bergl,Elizabeth V. Lonsdorf,Simon Myers,Mario Ventura,Pascal Gagneux,David Comas,Hans R. Siegismund,Julie Blanc,Lidia Agueda-Calpena,Marta Gut,Lucinda Fulton,Sarah A. Tishkoff,James C. Mullikin,Richard K. Wilson,Ivo Gut,Mary Katherine Gonder,Oliver A. Ryder,Beatrice H. Hahn,Arcadi Navarro,Arcadi Navarro,Joshua M. Akey,Jaume Bertranpetit,David Reich,Thomas Mailund,Mikkel H. Schierup,Christina Hvilsom,Christina Hvilsom,Aida M. Andrés,Jeffrey D. Wall,Carlos Bustamante,Michael F. Hammer,Evan E. Eichler,Evan E. Eichler,Tomas Marques-Bonet,Tomas Marques-Bonet +79 more
TL;DR: This comprehensive catalogue of great ape genome diversity provides a framework for understanding evolution and a resource for more effective management of wild and captive great ape populations.
Journal ArticleDOI
Insights into hominid evolution from the gorilla genome sequence
Aylwyn Scally,Julien Y. Dutheil,LaDeana W. Hillier,Gregory E. Jordan,Ian Goodhead,Javier Herrero,Asger Hobolth,Tuuli Lappalainen,Thomas Mailund,Tomas Marques-Bonet,Tomas Marques-Bonet,Tomas Marques-Bonet,Shane A. McCarthy,Stephen H. Montgomery,Petra C. Schwalie,Y. Amy Tang,Michelle C Ward,Yali Xue,Bryndis Yngvadottir,Can Alkan,Lars Nørvang Andersen,Qasim Ayub,Edward V. Ball,Kathryn Beal,Brenda J. Bradley,Brenda J. Bradley,Yuan Chen,Chris Clee,Stephen Fitzgerald,Tina Graves,Yong Gu,Paul Heath,Andreas Heger,Emre Karakoc,Anja Kolb-Kokocinski,Gavin K. Laird,Gerton Lunter,Stephen Meader,Matthew Mort,James C. Mullikin,Kasper Munch,Timothy D. O’Connor,Andrew David Phillips,Javier Prado-Martinez,Anthony Rogers,Saba Sajjadian,Dominic Schmidt,Katy Shaw,Jared T. Simpson,Peter D. Stenson,Daniel J. Turner,Linda Vigilant,Albert J. Vilella,Weldon Whitener,Baoli Zhu,David Neil Cooper,Pieter J. de Jong,Emmanouil T. Dermitzakis,Evan E. Eichler,Paul Flicek,Nick Goldman,Nicholas I. Mundy,Zemin Ning,Duncan T. Odom,Duncan T. Odom,Chris P. Ponting,Michael A. Quail,Oliver A. Ryder,Stephen M. J. Searle,Wesley C. Warren,Richard K. Wilson,Mikkel H. Schierup,Jane Rogers,Chris Tyler-Smith,Richard Durbin +74 more
TL;DR: A comparison of protein coding genes reveals approximately 500 genes showing accelerated evolution on each of the gorilla, human and chimpanzee lineages, and evidence for parallel acceleration, particularly of genes involved in hearing.
Journal ArticleDOI
Ancient gene flow from early modern humans into Eastern Neanderthals
Martin Kuhlwilm,Ilan Gronau,Melissa J. Hubisz,Cesare de Filippo,Javier Prado-Martinez,Martin Kircher,Qiaomei Fu,Hernán A. Burbano,Carles Lalueza-Fox,Marco de la Rasilla,Antonio Rosas,Pavao Rudan,Dejana Brajković,Željko Kućan,Ivan Gušić,Tomas Marques-Bonet,Tomas Marques-Bonet,Aida M. Andrés,Bence Viola,Svante Pääbo,Matthias Meyer,Adam Siepel,Adam Siepel,Sergi Castellano +23 more
TL;DR: It is concluded that in addition to later interbreeding events, the ancestors of Neanderthals from the Altai Mountains and early modern humans met and interbred, possibly in the Near East, many thousands of years earlier than previously thought.
Journal ArticleDOI
Derived immune and ancestral pigmentation alleles in a 7,000-year-old Mesolithic European
Iñigo Olalde,Morten E. Allentoft,Federico Sánchez-Quinto,Gabriel Santpere,Charleston W. K. Chiang,Michael DeGiorgio,Javier Prado-Martinez,Juan Antonio Rodríguez,Simon Rasmussen,Javier Quilez,Oscar Ramirez,Urko M. Marigorta,Marcos Fernandez-Callejo,María E. Prada,Julio Manuel Vidal Encinas,Rasmus Nielsen,Mihai G. Netea,John Novembre,Richard A. Sturm,Pardis C. Sabeti,Tomas Marques-Bonet,Arcadi Navarro,Eske Willerslev,Carles Lalueza-Fox +23 more
TL;DR: An approximately 7,000-year-old Mesolithic skeleton discovered at the La Braña-Arintero site in León, Spain, is sequenceed to retrieve a complete pre-agricultural European human genome, providing evidence that a significant number of derived, putatively adaptive variants associated with pathogen resistance in modern Europeans were already present in this hunter-gatherer.
Journal ArticleDOI
Mountain gorilla genomes reveal the impact of long-term population decline and inbreeding
Yali Xue,Javier Prado-Martinez,Peter H. Sudmant,Vagheesh M. Narasimhan,Vagheesh M. Narasimhan,Qasim Ayub,Michal Szpak,Peter Frandsen,Yuan Chen,Bryndis Yngvadottir,David Neil Cooper,Marc de Manuel,Jessica Hernandez-Rodriguez,Irene Lobon,Hans R. Siegismund,Luca Pagani,Luca Pagani,Michael A. Quail,Christina Hvilsom,Antoine Mudakikwa,Evan E. Eichler,Evan E. Eichler,Michael R. Cranfield,Tomas Marques-Bonet,Chris Tyler-Smith,Aylwyn Scally +25 more
TL;DR: It is found that the two eastern subspecies have experienced a prolonged population decline over the past 100,000 years, resulting in very low genetic diversity and an increased overall burden of deleterious variation.