M
Matthew Patrick
Researcher at University of Michigan
Publications - 68
Citations - 1307
Matthew Patrick is an academic researcher from University of Michigan. The author has contributed to research in topics: Biology & Medicine. The author has an hindex of 14, co-authored 47 publications receiving 661 citations. Previous affiliations of Matthew Patrick include University of Cambridge & University of York.
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Journal ArticleDOI
Atopic Dermatitis Is an IL-13–Dominant Disease with Greater Molecular Heterogeneity Compared to Psoriasis
Lam C. Tsoi,Elke Rodriguez,Frauke Degenhardt,Hansjörg Baurecht,Ulrike Wehkamp,Natalie Volks,Silke Szymczak,William R. Swindell,Mrinal K. Sarkar,Kalpana Raja,Shuai Shao,Matthew Patrick,Yilin Gao,Ranjitha Uppala,Bethany E. Perez White,Spiro Getsios,Paul W. Harms,Emanual Michael Maverakis,James T. Elder,James T. Elder,Andre Franke,Johann E. Gudjonsson,Stephan Weidinger +22 more
TL;DR: This study is by far the largest study comparing the AD and psoriasis transcriptomes using RNA sequencing and demonstrating the shared inflammatory components, as well as specific discordant cytokine signatures of these two skin diseases.
Journal ArticleDOI
Photosensitivity and type I IFN responses in cutaneous lupus are driven by epidermal-derived interferon kappa.
Mrinal K. Sarkar,Grace A. Hile,Lam C. Tsoi,Xianying Xing,Jianhua Liu,Yun Liang,Celine C. Berthier,William R. Swindell,Matthew Patrick,Shuai Shao,Pei-Suen Tsou,Ranjitha Uppala,Maria A. Beamer,Anshika Srivastava,Stephanie L. Bielas,Paul W. Harms,Spiro Getsios,James T. Elder,John J. Voorhees,Johann E. Gudjonsson,J. Michelle Kahlenberg +20 more
TL;DR: IFN-κ is identified as a critical IFN in CLE pathology via promotion of enhanced IFN responses and photosensitivity and is a potential novel target for UVB prophylaxis and CLE-directed therapy.
Journal ArticleDOI
Genetic signature to provide robust risk assessment of psoriatic arthritis development in psoriasis patients.
Matthew Patrick,Philip E. Stuart,Kalpana Raja,Kalpana Raja,Johann E. Gudjonsson,Trilokraj Tejasvi,Trilokraj Tejasvi,Jingjing Yang,Jingjing Yang,Vinod Chandran,Sayantan Das,Kristina Callis-Duffin,Eva Ellinghaus,Charlotta Enerbäck,Tõnu Esko,Tõnu Esko,Andre Franke,Hyun Min Kang,Gerald G. Krueger,Henry W. Lim,Proton Rahman,Cheryl F. Rosen,Stephan Weidinger,Michael Weichenthal,Xiaoquan Wen,John J. Voorhees,Gonçalo R. Abecasis,Dafna D. Gladman,Rajan P. Nair,James T. Elder,James T. Elder,Lam C. Tsoi +31 more
TL;DR: A computational pipeline involving statistical and machine-learning methods that can assess the risk of progression to PsA based on genetic markers is developed and it is shown that the underlying genetic differences between psoriasis subtypes can be used for individualized subtype risk assessment.
Journal ArticleDOI
Contribution of plasma cells and B-cells to hidradenitis suppurativa pathogenesis.
Johann E. Gudjonsson,Lam C. Tsoi,Feiyang Ma,Allison C. Billi,K R van Straalen,Allard R. J. V. Vossen,H.H. van der Zee,Paul W. Harms,Rachael Wasikowski,Christine M. Yee,Syed Monem Rizvi,Xianying Xing,Enze Xing,Olesya Plazyo,Chang Zeng,Matthew Patrick,Margaret M. Lowe,Richard E. Burney,Jeffrey H. Kozlow,Jill R. Cherry-Bukowiec,Yanyun Jiang,Joseph Kirma,Stephan Weidinger,Kelly C. Cushing,Michael Rosenblum,Celine C. Berthier,Amanda S. MacLeod,John J. Voorhees,Fei Wen,J. Michelle Kahlenberg,Emanual Michael Maverakis,Robert L. Modlin,Errol P. Prens +32 more
TL;DR: Preclinical evidence is provided to accelerate the path toward clinical trials targeting BTK and SYK signaling in moderate-to-severe HS, with Bruton’s tyrosine kinase (BTK) and spleen tyrosinase (SYK) pathway activation as a central signal transduction network in HS.
Journal ArticleDOI
Progression of acute-to-chronic atopic dermatitis is associated with quantitative rather than qualitative changes in cytokine responses
Lam C. Tsoi,Elke Rodriguez,Dora Stölzl,Ulrike Wehkamp,Jingru Sun,Sascha Gerdes,Mrinal K. Sarkar,Matthias Hübenthal,Chang Zeng,Ranjitha Uppala,Xianying Xing,Frederieke Thielking,Allison C. Billi,William R. Swindell,William R. Swindell,Alanna Shefler,Jiahan Chen,Matthew Patrick,Paul W. Harms,J. Michelle Kahlenberg,Bethany E. Perez White,Emanual Michael Maverakis,Johann E. Gudjonsson,Stephan Weidinger +23 more
TL;DR: The results show that the changes accompanying the transition from non-lesional to acute to chronic inflammation in AD are quantitative rather than qualitative, with chronic AD having heightened Th2, Th1, Th17, and IL36 responses and skin barrier repair mechanisms.