M
Mehmet Toner
Researcher at Harvard University
Publications - 572
Citations - 60830
Mehmet Toner is an academic researcher from Harvard University. The author has contributed to research in topics: Circulating tumor cell & Cancer. The author has an hindex of 113, co-authored 550 publications receiving 54827 citations. Previous affiliations of Mehmet Toner include University of New Mexico & University of Notre Dame.
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Journal ArticleDOI
Expression of Liver-Specific Functions by Rat Hepatocytes Seeded in Treated Poly(Lactic-co-Glycolic) Acid Biodegradable Foams
Vasif Hasirci,Francois Berthiaume,S.P. Bondre,Joseph D. Gresser,Debra J. Trantolo,Mehmet Toner,Donald L. Wise +6 more
TL;DR: PLGA foams, treated and untreated, represent a promising scaffold for scaling up hepatocyte cultures and may be a substitute for transplantation in patients whose livers can regenerate.
Journal ArticleDOI
Cellular response of mouse oocytes to freezing stress: prediction of intracellular ice formation.
TL;DR: An analytical model is developed to predict ice formation inside mouse oocytes subjected to a freezing stress and excellent agreement between predictions and observations suggests that the proposed model of IIF is adequate.
Journal ArticleDOI
Analysis of oxygen transport to hepatocytes in a flat-plate microchannel bioreactor.
TL;DR: Hepatocytes with oxygen dependent functional heterogeneity may exhibit optimal function in the bioreactor with the internal membrane oxygenator and can avoid cell hypoxia by appropriate selection of membrane Sherwood number and/or the gas phase oxygen partial pressure, thus providing greater control of cell oxygenation.
Squishy Non-Spherical Hydrogel Microparticles
TL;DR: This work reports the synthesis of soft polymeric colloids with sizes and shapes that mimic those of the RBC and demonstrates that the mechanical flexibility of the colloids can be reproducibly varied over a large range resulting in RBC-like deformability under physiological flow conditions.
Journal ArticleDOI
Ultrahigh-throughput magnetic sorting of large blood volumes for epitope-agnostic isolation of circulating tumor cells
Avanish Mishra,Taronish D. Dubash,Jon F. Edd,Michelle K. Jewett,Suhaas G Garre,Nezihi Murat Karabacak,Nezihi Murat Karabacak,Daniel C. Rabe,Baris R. Mutlu,John R. Walsh,Ravi Kapur,Shannon L. Stott,Shyamala Maheswaran,Daniel A. Haber,Daniel A. Haber,Mehmet Toner +15 more
TL;DR: An ultrahigh-throughput microfluidic chip, LPCTC-iChip, is described, that rapidly sorts through an entire leukapheresis product of over 6 billion nucleated cells, increasing CTC isolation capacity by two orders of magnitude (86% recovery with 105 enrichment).