M
Mehmet Toner
Researcher at Harvard University
Publications - 572
Citations - 60830
Mehmet Toner is an academic researcher from Harvard University. The author has contributed to research in topics: Circulating tumor cell & Cancer. The author has an hindex of 113, co-authored 550 publications receiving 54827 citations. Previous affiliations of Mehmet Toner include University of New Mexico & University of Notre Dame.
Papers
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Journal ArticleDOI
Induction of Apoptosis in Response to Anhydrobiotic Conditions in Mammalian Cells
TL;DR: The hypothesis that apoptosis contributes to cell death following anhydrobiotic preservation through the activation of multiple pathways by the complex array of stressors associated with the desiccation process is tested.
Journal ArticleDOI
Mutant mice derived by ICSI of evaporatively dried spermatozoa exhibit expected phenotype
Ming Wen Li,Brian Baridon,Amanda G. Trainor,Esi Djan,Amanda Koehne,Stephen M Griffey,John D. Biggers,Mehmet Toner,Kevin C K Lloyd +8 more
TL;DR: It is concluded that the expected phenotype caused by an induced genetic mutation can be faithfully recapitulated and sustained in subsequent generations of mice preserved and stored as ED spermatozoa and recovered using ICSI.
Journal ArticleDOI
Evaluation of endocrine resistance using ESR1 genotyping of circulating tumor cells and plasma DNA
Tilak K. Sundaresan,Taronish D. Dubash,Zongli Zheng,Aditya Bardia,Ben S. Wittner,Nicola Aceto,Nicola Aceto,Erin J. Silva,Douglas B. Fox,Matthew Liebers,Ravi Kapur,John Iafrate,Mehmet Toner,Shyamala Maheswaran,Daniel A. Haber +14 more
TL;DR: In this article, a prospective cohort of 55 women with hormone receptor-positive metastatic breast cancer, isolated circulating tumor cells (CTCs) and developed a high-sensitivity method for the detection of ESR1 mutations in these CTCs.
Patent
Capture and release of particles from liquid samples
TL;DR: In this paper, a first layer of gelatin is functionalized with a plurality of first members of a binding pair and a second layer is bound to the first layer via the second members of the binding pair.
Journal ArticleDOI
Relationship between hepatocellular carcinoma circulating tumor cells and tumor volume
Rahmi Oklu,Rahul A. Sheth,Hassan Albadawi,Irun Bhan,A. Fatih Sarioglu,Melissa Choz,Melissa Choz,Mahnaz Zeinali,Vikram Deshpande,Shyamala Maheswaran,Daniel A. Haber,Daniel A. Haber,Shannon L. Stott,Shannon L. Stott,Andrew X. Zhu,Lipika Goyal,Mehmet Toner,Mehmet Toner,David T. Ting +18 more
TL;DR: HCC CTCs provide additional data about the tumor independent of standard imaging and blood biomarkers, and there may be biological differences in small volume tumors that facilitate CTC entry into the blood stream.