Mehmet Toner

TL;DR: Investigation of the viability and synthetic function of rat hepatocytes cocultured with 3T3-J2 fibroblasts in a small-scale microchannel flat-plate bioreactor with and without an internal membrane oxygenator under flow showed that theBioreactor without the oxygenator resulted in significantly decreased viability and function of hepatocytes, whereas hepatocytes in the bioreactors with internal membranes oxygenator were able to maintain their viability andfunction.

TL;DR: Developments indicate that a new paradigm, integrating multiple existing preservation approaches and new technologies that have flourished in the past 10 years, could transform preservation research.

TL;DR: Recent strategies that combine nano- and microscale materials and devices to produce large improvements in detection sensitivity, speed and accuracy, allowing previously undetectable biomarkers to be identified in clinical samples are reviewed.

TL;DR: In this paper, the T790M gatekeeper mutation in the EGFR is acquired by some NSCLC patients as they become resistant to selective tyrosine kinase inhibitors (TKI).

TL;DR: Combined treatment with paclitaxel and Notch inhibitors achieves sustained suppression of tumorigenesis in orthotopic circulating tumour cell-derived tumour models and points to distinct yet interconverting phenotypes within patient-derived circulating tumours, contributing to progression of breast cancer and acquisition of drug resistance.