Mehmet Toner

TL;DR: The data suggest that fibroblast number plays a role in modulation of hepatocellular response through homotypic fibro Blast interactions, and this approach will allow further elucidation of the complex interplay between two cell types as they form a functional model tissue in vitro or as they interact in vivo to form afunctional organ.

TL;DR: Micropatterns of collagen or fibronectin were used to selectively adhere cells on various biomedical polymers and on heterogeneous or microtextured substrates to provide inexpensive patterning of a rich assortment of biomolecules, cells, and surfaces under physiological conditions.

TL;DR: Microfluidic capture of circulating tumor cells (CTC) is used to measure AR signaling readouts before and after therapeutic interventions to help target treatments to patients most likely to respond to second-line therapies.

TL;DR: This manuscript presents a microfabrication-derived approach for controlling mammalian cell−surface interactions by patterning high-density arrays of micrometer-scale PEG hydrogel wells on glass to induce hepatocyte attachment.

TL;DR: Progress is reported toward the goal of realizing an array of primary hepatocytes for use in high-throughput liver toxicity studies through the development of a 64- element array of microfluidic wells capable of supporting micropatterned primary rat hepatocytes in coculture with 3T3-J2 fibroblasts.