M
Mehmet Toner
Researcher at Harvard University
Publications - 572
Citations - 60830
Mehmet Toner is an academic researcher from Harvard University. The author has contributed to research in topics: Circulating tumor cell & Cancer. The author has an hindex of 113, co-authored 550 publications receiving 54827 citations. Previous affiliations of Mehmet Toner include University of New Mexico & University of Notre Dame.
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Effect of cell–cell interactions in preservation of cellular phenotype: cocultivation of hepatocytes and nonparenchymal cells
TL;DR: Although the precise mechanisms by which nonparenchymal cells modulate the hepatocyte phenotype remain unelucidated, some new insights on the modes of cell signaling, the extent of cell–cell interaction, and the ratio of cell populations are noted.
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Ex vivo culture of circulating breast tumor cells for individualized testing of drug susceptibility
Min Yu,Min Yu,Aditya Bardia,Nicola Aceto,Francesca Bersani,Marissa W. Madden,Maria C. Donaldson,Rushil Desai,Huili Zhu,Valentine Comaills,Zongli Zheng,Zongli Zheng,Ben S. Wittner,Petar Stojanov,Elena F. Brachtel,Dennis C. Sgroi,Ravi Kapur,Toshihiro Shioda,David T. Ting,Sridhar Ramaswamy,Gad Getz,Gad Getz,A. John Iafrate,Cyril H. Benes,Mehmet Toner,Shyamala Maheswaran,Daniel A. Haber,Daniel A. Haber +27 more
TL;DR: It has been proposed that the isolation, ex vivo culture, and characterization of CTCs may provide an opportunity to noninvasively monitor the changing patterns of drug susceptibility in individual patients as their tumors acquire new mutations.
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Multifunctional encoded particles for high-throughput biomolecule analysis.
TL;DR: This work presents a method based on continuous-flow lithography that combines particle synthesis and encoding and probe incorporation into a single process to generate multifunctional particles bearing over a million unique codes that can be scanned rapidly in a flow-through microfluidic channel.
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Microfluidic, marker-free isolation of circulating tumor cells from blood samples
Nezihi Murat Karabacak,Philipp S. Spuhler,Fabio Fachin,Eugene J. Lim,Vincent Pai,Emre Ozkumur,Joseph M. Martel,Nikola Kojic,Kyle C. Smith,Pin-i Chen,Jennifer Yang,Henry H. Hwang,Bailey Morgan,Julie Trautwein,Tom Barber,Shannon L. Stott,Shyamala Maheswaran,Ravi Kapur,Daniel A. Haber,Mehmet Toner +19 more
TL;DR: The procedure for isolating rare CTCs from blood samples by using tumor antigen–independent microfluidic CTC-iChip technology, which uses deterministic lateral displacement, inertial focusing and magnetophoresis to sort up to 107 cells/s.
Journal ArticleDOI
Microengineering of Cellular Interactions
Albert Folch,Mehmet Toner +1 more
TL;DR: This article reviews past research on the engineering of cell-substrate, cell-cell, and cell-medium interactions on the micrometer scale and suggests ways to design surfaces that reproduce some of the aspects of that architecture.