M
Mehmet Toner
Researcher at Harvard University
Publications - 572
Citations - 60830
Mehmet Toner is an academic researcher from Harvard University. The author has contributed to research in topics: Circulating tumor cell & Cancer. The author has an hindex of 113, co-authored 550 publications receiving 54827 citations. Previous affiliations of Mehmet Toner include University of New Mexico & University of Notre Dame.
Papers
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Journal ArticleDOI
Cryomicroscopic analysis of intracellular ice formation in mouse oocytes
Book ChapterDOI
Negative-Selection Enrichment of Circulating Tumor Cells from Peripheral Blood Using the Microfluidic CTC-iChip.
Risa Burr,Jon F. Edd,Brian Chirn,Avanish Mishra,Daniel A. Haber,Mehmet Toner,Shyamala Maheswaran +6 more
TL;DR: A negative-selection protocol for enrichment of CTCs through removal of blood components including red blood cells, platelets, and white blood cells is described, which results in a product that is amenable to downstream single-cell analytics.
Journal ArticleDOI
Downregulation of KEAP1 in melanoma promotes resistance to immune checkpoint blockade
Douglas B. Fox,Richard H. Ebright,Xin Hong,Hunter C. Russell,Hongshan Guo,Thomas J. LaSalle,Ben S. Wittner,Nicolas Poux,Joanna Vuille,Mehmet Toner,Nir Hacohen,Genevieve M. Boland,Debattama R. Sen,Ryan J. Sullivan,Shyamala Maheswaran,Daniel A. Haber +15 more
TL;DR: In this paper , the authors used single cell RNA sequencing of melanoma patient-derived circulating tumor cells (CTCs) and functional characterization using mouse melanoma models to show that the KEAP1/NRF2 pathway modulates sensitivity to ICB, independently of tumorigenesis.
Journal ArticleDOI
C-37: Measurement of intracellular water and trehalose in desiccated cells
TL;DR: This was the first study to probe into desiccated cells at the single-cell level and to quantify intracellular water and trehalose contents and distributions, which are essential information for studies on storage stability of desiccation cells.
Proceedings ArticleDOI
Abstract PL06-04: Molecular characterization of circulating tumor cells.
Daniel A. Haber,Shyamala Maheswaran,Lecia V. Sequist,Min Yu,Emre Ozkumur,David T. Ting,David T. Miyamoto,Richard T. Lee,Ajay Shah,Aditya Bardia,Shannon L. Stott,Mehmet Toner +11 more
TL;DR: The application of novel bioengineering technologies to the isolation and analysis of CTCs across multiple different cancer types offers a unique window into the properties of cancer cells that invade into the bloodstream and give rise to metastases.