M
Michael D. Buck
Researcher at Francis Crick Institute
Publications - 35
Citations - 7722
Michael D. Buck is an academic researcher from Francis Crick Institute. The author has contributed to research in topics: T cell & Dengue virus. The author has an hindex of 21, co-authored 34 publications receiving 5539 citations. Previous affiliations of Michael D. Buck include La Jolla Institute for Allergy and Immunology & Washington University in St. Louis.
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Journal ArticleDOI
Fever supports CD8+ effector T cell responses by promoting mitochondrial translation.
David O’Sullivan,Michal A. Stanczak,Matteo Villa,Franziska M. Uhl,Franziska M. Uhl,Mauro Corrado,Ramon I. Klein Geltink,David E. Sanin,Petya Apostolova,Nisha Rana,Joy Edwards-Hicks,Katarzyna M. Grzes,Agnieszka M. Kabat,Ryan Kyle,Mario Fabri,Jonathan D. Curtis,Michael D. Buck,Annette E. Patterson,Annamaria Regina,Annamaria Regina,Cameron S. Field,Francesc Baixauli,Daniel J. Puleston,Edward J. Pearce,Edward J. Pearce,Robert Zeiser,Erika L. Pearce +26 more
TL;DR: In this article, the effect of febrile temperature on T cell metabolism has been investigated in vitro and in vivo models, and it was shown that mitochondrial translation is integral to the enhanced metabolic activity and function of activated CD8+ T cells exposed to 39 °C.
Journal ArticleDOI
Tracking the Evolution of Dengue Virus Strains D2S10 and D2S20 by 454 Pyrosequencing
TL;DR: D2S20 is more virulent than D2S10 and the presence of five key amino acid mutations – T70I, N83D, and K122I in envelope (E), and A62T in nonstructural protein 2A (NS2A) and G605V in non Structural protein 5 (NS5) – that may account for this are captured.
Journal ArticleDOI
Tonic TCR Signaling Inversely Regulates the Basal Metabolism of CD4+ T Cells.
Ashley A. Viehmann Milam,Juliet M. Bartleson,Michael D. Buck,Michael D. Buck,Chih-Hao Chang,Alexey Sergushichev,David L. Donermeyer,Wing Y. Lam,Erika L. Pearce,Maxim N. Artyomov,Paul M. Allen +10 more
TL;DR: This study employed LLO118 and LLO56, two TCRtg CD4+ T cells that recognize the same Listeria epitope and hypothesized that the decreased metabolism resulting from a strong interaction with self was mediated through TCR signaling, supporting this hypothesis.
Posted ContentDOI
Standard operating procedures for SARS-CoV-2 detection by a clinical diagnostic RT-LAMP assay
Michael D. Buck,Enzo Z. Poirier,Ana Cardoso,Bruno Frederico,Johnathan Canton,Sam Barrell,Rupert Beale,Rupert Beale,Richard D. Byrne,Simon Caidan,Margaret Crawford,Laura Cubitt,Steve Gamblin,Sonia Gandhi,Sonia Gandhi,Sonia Gandhi,Robert J. Goldstone,Paul Grant,Kiran Gulati,Steve Hindmarsh,Michael Howell,Mike Hubank,Mike Hubank,Rachael Instrell,Ming Jiang,George Kassiotis,Wei-Ting Lu,James I. MacRae,Iana Martini,Davin Miller,David Moore,David Moore,Eleni Nastouli,Eleni Nastouli,Jerome Nicod,Luke Nightingale,Jessica Olsen,Amin Oomatia,Nicola O’Reilly,Anett Rideg,Ok-Ryul Song,Amy Strange,Charles Swanton,Charles Swanton,Charles Swanton,Samra Turajlic,Samra Turajlic,Philip A. Walker,Mary Wu,Caetano Reis e Sousa +49 more
TL;DR: This work presents a clinically-validated standard operating procedure (SOP) for high-throughput SARS- CoV-2 detection by RT-LAMP in 25 minutes that is robust, reliable, repeatable, sensitive, specific, and inexpensive.
Journal ArticleDOI
SARS-CoV-2 detection by a clinical diagnostic RT-LAMP assay
Michael D. Buck,Enzo Z. Poirier,Ana Cardoso,Bruno Frederico,Johnathan Canton,Sam Barrell,Rupert Beale,Richard D. Byrne,Simon Caidan,Margaret Crawford,Laura Cubitt,Sonia Gandhi,Sonia Gandhi,Robert L. Goldstone,Paul Grant,Kiran Gulati,Steve Hindmarsh,Michael Howell,Mike Hubank,Mike Hubank,Rachael Instrell,Ming Jiang,George Kassiotis,Wei-Ting Lu,James I. MacRae,Iana Martini,Davin Miller,David Moore,Eleni Nastouli,Eleni Nastouli,Jerome Nicod,Luke Nightingale,Jessica Olsen,Amin Oomatia,Nicola O’Reilly,Anett Rideg,Ok-Ryul Song,Amy Strange,Charles Swanton,Charles Swanton,Samra Turajlic,Samra Turajlic,Mary Wu,Caetano Reis e Sousa +43 more
TL;DR: This work presents a clinically-validated procedure for high-throughput SARS-CoV-2 detection by RT-LAMP in 25 minutes that is robust, reliable, repeatable, sensitive, specific, and inexpensive.