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Rebecca A. Barnetson
Researcher at University of Edinburgh
Publications - 27
Citations - 4470
Rebecca A. Barnetson is an academic researcher from University of Edinburgh. The author has contributed to research in topics: Cancer & Population. The author has an hindex of 22, co-authored 27 publications receiving 4269 citations. Previous affiliations of Rebecca A. Barnetson include Western General Hospital & Edinburgh Cancer Research Centre.
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Journal ArticleDOI
Genome-wide association scan identifies a colorectal cancer susceptibility locus on 11q23 and replicates risk loci at 8q24 and 18q21.
Albert Tenesa,Susan M. Farrington,James G. D. Prendergast,Mary Porteous,Marion F Walker,Naila Haq,Rebecca A. Barnetson,Evropi Theodoratou,Roseanne Cetnarskyj,Nicola Cartwright,Colin A. Semple,Andrew G. Clark,Fiona Reid,Lorna Smith,Kostas Kavoussanakis,Thibaud Koessler,Paul D.P. Pharoah,Stephan Buch,Clemens Schafmayer,Jürgen Tepel,Stefan Schreiber,Henry Völzke,Carsten Oliver Schmidt,Jochen Hampe,Jenny Chang-Claude,Michael Hoffmeister,Hermann Brenner,Stefan Wilkening,Federico Canzian,Gabriel Capellá,Victor Moreno,Ian J. Deary,John M. Starr,Ian Tomlinson,Zoe Kemp,Kimberley Howarth,Luis G. Carvajal-Carmona,Emily L. Webb,Peter Broderick,Jayaram Vijayakrishnan,Richard S. Houlston,Gad Rennert,Dennis G. Ballinger,Laura S. Rozek,Stephen B. Gruber,Koichi Matsuda,Tomohide Kidokoro,Yusuke Nakamura,Brent W. Zanke,Brent W. Zanke,Brent W. Zanke,Celia M. T. Greenwood,Celia M. T. Greenwood,Jagadish Rangrej,Jagadish Rangrej,Rafal Kustra,Alexandre Montpetit,Thomas J. Hudson,Thomas J. Hudson,Steven Gallinger,Steven Gallinger,Harry Campbell,Malcolm G. Dunlop +62 more
TL;DR: Findings extend the understanding of the role of common genetic variation in CRC etiology by identifying a previously unreported association, rs3802842 on 11q23, and carrying all six possible risk alleles yielded OR = 2.6 (95% CI = 1.75–3.89) for CRC.
Journal ArticleDOI
Meta-analysis of genome-wide association data identifies four new susceptibility loci for colorectal cancer
Richard S. Houlston,Emily L. Webb,Peter Broderick,Alan M. Pittman,Maria Chiara Di Bernardo,Steven J. Lubbe,Ian Chandler,Jayaram Vijayakrishnan,Kate Sullivan,Steven Penegar,Luis G. Carvajal-Carmona,Kimberley Howarth,Emma Jaeger,Sarah L. Spain,Axel Walther,Ella Barclay,Lynn Martin,Maggie Gorman,Enric Domingo,Ana Teixeira,David J. Kerr,Jean-Baptiste Cazier,Iina Niittymäki,Sari Tuupanen,Auli Karhu,Lauri A. Aaltonen,Ian Tomlinson,Susan M. Farrington,Albert Tenesa,James Prendergast,Rebecca A. Barnetson,Roseanne Cetnarskyj,Mary Porteous,Paul D.P. Pharoah,Thibaud Koessler,Jochen Hampe,Stephan Buch,Clemens Schafmayer,Jürgen Tepel,Stefan Schreiber,Henry Völzke,Jenny Chang-Claude,Michael Hoffmeister,Hermann Brenner,Brent W. Zanke,Alexandre Montpetit,Thomas J. Hudson,Thomas J. Hudson,Thomas J. Hudson,Steven Gallinger,Steven Gallinger,Harry Campbell,Malcolm G. Dunlop +52 more
TL;DR: Four previously unreported CRC risk loci are identified at 14q22.2, highlighting the value of large sample series for discovery and follow-up of genetic variants contributing to the etiology of CRC.
Journal ArticleDOI
A genome-wide association study identifies colorectal cancer susceptibility loci on chromosomes 10p14 and 8q23.3
Ian Tomlinson,Emily L. Webb,Luis G. Carvajal-Carmona,Peter Broderick,Kimberley Howarth,Alan M. Pittman,Sarah L. Spain,Steven J. Lubbe,Axel Walther,Kate Sullivan,Emma Jaeger,Sarah Fielding,Andrew Rowan,Jayaram Vijayakrishnan,Enric Domingo,Ian Chandler,Zoe Kemp,Mobshra Qureshi,Susan M. Farrington,Albert Tenesa,James G. D. Prendergast,Rebecca A. Barnetson,Steven Penegar,Ella Barclay,Wendy Wood,Lynn Martin,Lynn Martin,Lynn Martin,Maggie Gorman,Huw Thomas,Julian Peto,D. Timothy Bishop,Richard Gray,Eamonn R. Maher,Anneke Lucassen,David J. Kerr,D. Gareth Evans,Clemens Schafmayer,Stephan Buch,Henry Völzke,Jochen Hampe,Stefan Schreiber,Ulrich John,Thibaud Koessler,Paul D.P. Pharoah,Tom van Wezel,Hans Morreau,Juul T. Wijnen,John L. Hopper,Melissa C. Southey,Graham G. Giles,Graham G. Giles,Gianluca Severi,Sergi Castellví-Bel,Clara Ruiz-Ponte,Angel Carracedo,Antoni Castells,Asta Försti,Asta Försti,Kari Hemminki,Kari Hemminki,Pavel Vodicka,Alessio Naccarati,Lara Lipton,Judy W. C. Ho,King Yip Cheng,Pak C. Sham,John M. Luk,José A. G. Agúndez,José M. Ladero,Miguel de la Hoya,Trinidad Caldés,Iina Niittymäki,Sari Tuupanen,Auli Karhu,Lauri A. Aaltonen,Jean-Baptiste Cazier,Harry Campbell,Malcolm G. Dunlop,Richard S. Houlston +79 more
TL;DR: Genetic data provide further evidence for the 'common-disease common-variant' model of CRC predisposition and identify two previously unreported associations.
Journal ArticleDOI
Identification and Survival of Carriers of Mutations in DNA Mismatch-Repair Genes in Colon Cancer
Rebecca A. Barnetson,Albert Tenesa,Susan M. Farrington,Iain D. Nicholl,Roseanne Cetnarskyj,Mary Porteous,Harry Campbell,Harry Campbell,Malcolm G. Dunlop +8 more
TL;DR: A two-stage model by multivariate logistic regression was developed and validated and was robust among a wide range of cutoff probabilities and was superior to that of the Bethesda and Amsterdam criteria for hereditary nonpolyposis colorectal cancer.
Journal ArticleDOI
Meta-analysis of three genome-wide association studies identifies susceptibility loci for colorectal cancer at 1q41, 3q26.2, 12q13.13 and 20q13.33
Richard S. Houlston,Jeremy Peter Cheadle,Sara E. Dobbins,Albert Tenesa,Angela M. Jones,Kimberley Howarth,Sarah L. Spain,Peter Broderick,Enric Domingo,Susan M. Farrington,James G. D. Prendergast,Alan M. Pittman,Evi Theodoratou,Christopher Smith,Bianca Olver,Axel Walther,Rebecca A. Barnetson,Michael Churchman,Emma Jaeger,Steven Penegar,Ella Barclay,Lynn Martin,Maggie Gorman,Rachel Mager,Elaine C. Johnstone,Rachel Midgley,Iina Niittymäki,Sari Tuupanen,James Colley,Shelley Idziaszczyk,Huw Thomas,Anneke Lucassen,D. Gareth Evans,Eamonn R. Maher,Tim Maughan,Antigone S. Dimas,Antigone S. Dimas,Emmanouil T. Dermitzakis,Jean-Baptiste Cazier,Lauri A. Aaltonen,Paul D.P. Pharoah,David J. Kerr,David J. Kerr,Luis G. Carvajal-Carmona,Harry Campbell,Malcolm G. Dunlop,Ian Tomlinson +46 more
TL;DR: A meta-analysis of three GWAS from the UK provides evidence that additional CRC-associated variants of similar effect size remain to be discovered and identifies four new CRC risk loci.