Michael Kiening

TL;DR: Today's best protein function prediction algorithms substantially outperform widely used first-generation methods, with large gains on all types of targets, and there is considerable need for improvement of currently available tools.

TL;DR: This work describes a few methods that predict protein function exclusively through homology and proposes a new rigorous measure to compare predicted and experimental annotations that puts more emphasis on the details of protein function than the other measures employed by CAFA and may best reflect the expectations of users.

TL;DR: This is the first compilation of potentially functional conserved RNA structures in viral coding regions, covering the complete RefSeq viral database, and was able to recover structural elements from previous studies and discovered a variety of novel structured regions.

TL;DR: Within the phylogenetic virus groups sets of conserved functional structures are present, but that between the groups conservation is low to non-existent, implying that the genetic strategy of having an ambisense RNA genome has evolved several times independently.

TL;DR: This study highlights the intrinsic adaptation of water kefir-borne L. hordei to sucrose-rich habitats and provides fundamental knowledge for its use as a starter culture in plant-based food fermentations with in situ dextran formation.