M
Mirco Castoldi
Researcher at Heidelberg University
Publications - 30
Citations - 6201
Mirco Castoldi is an academic researcher from Heidelberg University. The author has contributed to research in topics: microRNA & Gene expression. The author has an hindex of 18, co-authored 23 publications receiving 5779 citations. Previous affiliations of Mirco Castoldi include Molecular Medicine Partnership Unit & University of Düsseldorf.
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Journal ArticleDOI
MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts
Thomas Thum,Carina Gross,Jan Fiedler,Thomas Fischer,Stephan Kissler,Markus Bussen,Paolo Galuppo,Steffen Just,Wolfgang Rottbauer,Stefan Frantz,Mirco Castoldi,Jürgen Soutschek,Victor Koteliansky,Andreas Rosenwald,M. Albert Basson,Jonathan D. Licht,John T. R. Pena,Sara H. Rouhanifard,Martina U. Muckenthaler,Thomas Tuschl,Gail R. Martin,Johann Bauersachs,Stefan Engelhardt,Stefan Engelhardt +23 more
TL;DR: It is shown that microRNA-21 regulates the ERK–MAP kinase signalling pathway in cardiac fibroblasts, which has impacts on global cardiac structure and function and confirms miR-21 as a disease target in heart failure and establishes the therapeutic efficacy of microRNA therapeutic intervention in a cardiovascular disease setting.
Journal ArticleDOI
Replicative senescence of mesenchymal stem cells: a continuous and organized process.
Wolfgang Wagner,Patrick Horn,Mirco Castoldi,Anke Diehlmann,Simone Bork,Rainer Saffrich,Vladimir Benes,Jonathon Blake,Stefan M. Pfister,Volker Eckstein,Anthony D. Ho +10 more
TL;DR: The studies indicate that replicative senescence of MSC preparations is a continuous process starting from the first passage onwards, which includes far reaching alterations in phenotype, differentiation potential, global gene expression patterns, and miRNA profiles that need to be considered for therapeutic application of M SC preparations.
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Micro-RNA profiling reveals a role for miR-29 in human and murine liver fibrosis
Christoph Roderburg,Gerd-Willem Urban,Kira Bettermann,Mihael Vucur,Henning W. Zimmermann,Sabine Schmidt,Jörn Janssen,Christiane Koppe,Percy A. Knolle,Mirco Castoldi,Mirco Castoldi,Frank Tacke,Christian Trautwein,Tom Luedde +13 more
TL;DR: The data indicate that miR‐29 mediates the regulation of liver fibrosis and is part of a signaling nexus involving TGF‐β‐ and NF‐κB–dependent down‐regulation of miR-29 family members in HSC with subsequent up‐ regulation of extracellular matrix genes.
Journal ArticleDOI
A sensitive array for microRNA expression profiling (miChip) based on locked nucleic acids (LNA).
Mirco Castoldi,Sabine Schmidt,Vladimir Benes,Mikkel Noerholm,Andreas E. Kulozik,Matthias W. Hentze,Martina U. Muckenthaler +6 more
TL;DR: A novel microarray platform for genome-wide profiling of mature miRNAs (miChip) using locked nucleic acid (LNA)-modified capture probes using superior detection sensitivity eliminates the need for RNA size selection and/or amplification.
Journal ArticleDOI
Expression of the miR-17-92 polycistron in chronic myeloid leukemia (CML) CD34+ cells
Letizia Venturini,Karin Battmer,Mirco Castoldi,Beate Schultheis,Andreas Hochhaus,Martina U. Muckenthaler,Arnold Ganser,Matthias Eder,Michaela Scherr +8 more
TL;DR: BCR-ABL- and c-MYC-dependent regulation of miRNA expression in chronic myeloid leukemia (CML) is reported using microarray analysis (miCHIP) and miRNA-specific quantitative real-time reverse transcriptase-polymerase chain reaction (miR-qRT-PCR).