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Nancy A. Jenkins
Researcher at Houston Methodist Hospital
Publications - 743
Citations - 105243
Nancy A. Jenkins is an academic researcher from Houston Methodist Hospital. The author has contributed to research in topics: Gene & Gene mapping. The author has an hindex of 155, co-authored 741 publications receiving 101587 citations. Previous affiliations of Nancy A. Jenkins include Institute of Molecular and Cell Biology & University of Texas MD Anderson Cancer Center.
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Journal ArticleDOI
Reversal of left-right asymmetry : a situs inversus mutation
Takahiko Yokoyama,Neal G. Copeland,Nancy A. Jenkins,Charles A. Montgomery,Frederick F.B. Elder,Paul A. Overbeek +5 more
TL;DR: A recessive mutation was identified in a family of transgenic mice that resulted in a reversal of left-right polarity (situs inversus) in 100 percent of the homozygoustransgenic mice tested, identifying a gene that controls embryonic turning and visceral left- right polarity.
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The mouse waved-2 phenotype results from a point mutation in the EGF receptor tyrosine kinase.
Noreen C. Luetteke,H K Phillips,T H Qiu,Neal G. Copeland,H S Earp,Nancy A. Jenkins,David C. Lee +6 more
TL;DR: In situ hybridization analysis demonstrated expression of EGFR predominantly in the outer root sheath of active hair follicles in neonatal mice, consistent with the effect of the wa-2 mutation on hair structure, and together with the previous characterization of TGF-alpha-deficient mice, reveals a critical role for signaling by this ligand/receptor system in skin.
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A Large Family of Putative Transmembrane Receptors Homologous to the Product of the Drosophila Tissue Polarity Gene frizzled
Yanshu Wang,Jennifer P. Macke,Benjamin S. Abella,Katrin I. Andreasson,Paul F. Worley,Debra J. Gilbert,Neal G. Copeland,Nancy A. Jenkins,Jeremy Nathans +8 more
TL;DR: Observations predict the existence of a family of signal transduction pathways that are homologous to the pathway that determines tissue polarity in Drosophila.
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Identification of an organelle receptor for myosin-Va
Xufeng S. Wu,Kang Rao,Hong Zhang,Fei Wang,James R. Sellers,Lydia E. Matesic,Neal G. Copeland,Nancy A. Jenkins,John A. Hammer +8 more
TL;DR: The results provide the first molecular description of an organelle receptor for an actin-based motor, illustrate how alternate exon usage can be used to specify cargo, and further expand the functional repertoire of Rab GTPases and their effectors.
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Fibroblast growth factor (FGF) homologous factors: New members of the FGF family implicated in nervous system development
Philip M. Smallwood,Ignacio Munoz-Sanjuan,Patrick Y Tong,Jennifer P. Macke,Stewart H. C. Hendry,Debra J. Gilbert,Neal G. Copeland,Nancy A. Jenkins,Jeremy Nathans +8 more
TL;DR: Each FHF is expressed in the developing and adult nervous systems, suggesting a role for this branch of the FGF family in nervous system development and function.