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Nancy A. Jenkins
Researcher at Houston Methodist Hospital
Publications - 743
Citations - 105243
Nancy A. Jenkins is an academic researcher from Houston Methodist Hospital. The author has contributed to research in topics: Gene & Gene mapping. The author has an hindex of 155, co-authored 741 publications receiving 101587 citations. Previous affiliations of Nancy A. Jenkins include Institute of Molecular and Cell Biology & University of Texas MD Anderson Cancer Center.
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Journal ArticleDOI
Mitf and Tfe3, two members of the Mitf-Tfe family of bHLH-Zip transcription factors, have important but functionally redundant roles in osteoclast development
Eiríkur Steingrímsson,Lino Tessarollo,Bhavani G. Pathak,Ling Hou,Heinz Arnheiter,Neal G. Copeland,Nancy A. Jenkins +6 more
TL;DR: This work uncovers a role for Tfe3 in osteoclast development, a role that is functionally redundant with Mitf, and suggests that heterodimeric interactions are not essential for Mitf-Tfe function in contrast to other bHLH-Zip families like Myc/Max/Mad, where heterodimmeric interactions seem to be essential.
Journal ArticleDOI
Sleeping Beauty mutagenesis reveals cooperating mutations and pathways in pancreatic adenocarcinoma
Karen M. Mann,Jerrold M. Ward,Christopher Chin Kuan Yew,Anne N. Kovochich,David W. Dawson,Michael A. Black,Benjamin T. Brett,Todd E. Sheetz,Adam J. Dupuy,David K. Chang,David K. Chang,Andrew V. Biankin,Andrew V. Biankin,Nicola Waddell,Karin S. Kassahn,Sean M. Grimmond,Alistair G. Rust,David J. Adams,Nancy A. Jenkins,Neal G. Copeland +19 more
TL;DR: In this article, a mutagenic screen using Sleeping Beauty (SB) in mice to identify new candidate cancer genes in pancreatic cancer was conducted to identify 681 loci that comprise 543 cancer genes (CCGs).
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A conditional transposon-based insertional mutagenesis screen for genes associated with mouse hepatocellular carcinoma
Vincent W. Keng,Augusto Villanueva,Derek Y. Chiang,Adam J. Dupuy,Barbara J. Ryan,Ilze Matise,Kevin A. T. Silverstein,Aaron L. Sarver,Timothy K. Starr,Keiko Akagi,Lino Tessarollo,Lara S. Collier,Scott Powers,Scott W. Lowe,Nancy A. Jenkins,Neal G. Copeland,Josep M. Llovet,Josep M. Llovet,David A. Largaespada +18 more
TL;DR: A system that permits conditional mobilization of a Sleeping Beauty (SB) transposase allele by Cre recombinase to induce cancer specifically in a tissue of interest promises to enhance understanding of cancer genomes and identify new targets for therapeutic development.
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"Expression patterns of two murine homologs of Drosophila single-minded suggest possible roles in embryonic patterning and in the pathogenesis of Down syndrome.".
Chen-Ming Fan,Ellen Kuwana,Alessandro Bulfone,Colin F. Fletcher,Neal G. Copeland,Nancy A. Jenkins,Stephen T. Crews,Salvador Martinez,Luis Puelles,John L.R. Rubenstein,Marc Tessier-Lavigne +10 more
TL;DR: The identification of two murine homologs of sim, Sim1 and Sim2, whose products show a high degree of sequence conservation with Drosophila SIM in their amino-terminal halves, with each containing a basic helix-loop-helix domain as well as a PAS domain.
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Mouse models of human disease. Part I: techniques and resources for genetic analysis in mice.
TL;DR: In the vast majority of mouse models of human disease, the mouse mutant phenotype very closely resembles the human disease phenotype and these models provide valuable resources to understand how the diseases develop and to test ways to prevent or treat these diseases.