N
Nathan M Kallen
Researcher at Clark University
Publications - 3
Citations - 1405
Nathan M Kallen is an academic researcher from Clark University. The author has contributed to research in topics: Agaricomycetes & Agaricomycotina. The author has an hindex of 2, co-authored 3 publications receiving 1233 citations.
Papers
More filters
Journal ArticleDOI
The paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes
Dimitrios Floudas,Manfred Binder,Robert Riley,Kerrie Barry,Robert A. Blanchette,Bernard Henrissat,Ángel T. Martínez,Robert Otillar,Joseph W. Spatafora,Jagjit S. Yadav,Andrea Aerts,Isabelle Benoit,Alexander Boyd,Alexis Carlson,Alex Copeland,Pedro M. Coutinho,Ronald P. de Vries,Patricia Ferreira,Keisha Findley,Brian Foster,Jill Gaskell,Dylan Glotzer,Paweł Górecki,Joseph Heitman,Cedar N. Hesse,Chiaki Hori,Kiyohiko Igarashi,Joel A. Jurgens,Nathan M Kallen,Phil Kersten,Annegret Kohler,Ursula Kües,T. K. Arun Kumar,Alan Kuo,Kurt LaButti,Luis F. Larrondo,Erika Lindquist,Albee Y. Ling,Vincent Lombard,Susan Lucas,Taina Lundell,Rachael Martin,David J. McLaughlin,Ingo Morgenstern,Emanuelle Morin,Claude Murat,László Nagy,Matthew J Nolan,Robin A. Ohm,Aleksandrina Patyshakuliyeva,Antonis Rokas,Francisco J. Ruiz-Dueñas,Grzegorz Sabat,Asaf Salamov,Masahiro Samejima,Jeremy Schmutz,Jason C. Slot,Franz J. St John,Jan Stenlid,Hui Sun,Sheng Sun,Khajamohiddin Syed,Adrian Tsang,Ad Wiebenga,Darcy Young,Antonio G. Pisabarro,Daniel C. Eastwood,Francis Martin,Dan Cullen,Igor V. Grigoriev,David S. Hibbett +70 more
TL;DR: Comparative analyses of 31 fungal genomes suggest that lignin-degrading peroxidases expanded in the lineage leading to the ancestor of the Agaricomycetes, which is reconstructed as a white rot species, and then contracted in parallel lineages leading to brown rot and mycorrhizal species.
Journal ArticleDOI
CD117-Amanitin Antibody Drug Conjugates Effectively Deplete Human and Non-Human Primate HSCs: Proof of Concept As a Targeted Strategy for Conditioning Patients for Bone Marrow Transplant
Bradley R. Pearse,Sean McDonough,Jennifer L. Proctor,Rajiv Panwar,Ganapathy N. Sarma,Molly A McShea,Lena Kien,Junia Dushime,Hillary L. Adams,Sharon L. Hyzy,Melissa L. Brooks,Rahul Palchaudhuri,Qing Li,Nathan M Kallen,Pranoti Sawant,Charlotte Mcdonagh,Anthony E. Boitano,Michael P. Cooke +17 more
TL;DR: A potent anti-CD117 ADC highly effective in eliminating host HSCs with a short half-life and minimal adverse side effects in a non-human primate (NHP) model is developed, demonstrating that this strategy will spare the adaptive immune system.
Journal ArticleDOI
Single Doses of Antibody Drug Conjugates (ADCs) Targeted to CD117 or CD45 Have Potent In Vivo Anti-Leukemia Activity and Survival Benefit in Patient Derived AML Models
Jennifer L. Proctor,Sharon L. Hyzy,Hillary L. Adams,Melissa L. Brooks,Andrew D Gabros,Sean McDonough,Lena Kien,Sharon Aslanian,Bradley R. Pearse,Rahul Palchaudhuri,Qing Li,Nathan M Kallen,Ganapathy N. Sarma,Molly A McShea,Danielle Ladwig,Junia Dushime,Rajiv Panwar,Charlotte Mcdonagh,Anthony E. Boitano,Michael P. Cooke +19 more
TL;DR: The aim of the project was to design an agent with the dual benefit of depleting primary human hematopoietic stem progenitor cells (HSPCs) while reducing disease burden in leukemia models.