Chia-An Yen

TL;DR: A comprehensive chromatin interaction map generated in human fibroblasts using a genome-wide 3C analysis method (Hi-C) is reported and suggests that the three-dimensional chromatin landscape, once established in a particular cell type, is relatively stable and could influence the selection of target genes by a ubiquitous transcription activator in a cell-specific manner.

TL;DR: It is found that promoters that are active in early developmental stages tend to be CG rich and mainly engage H3K27me3 upon silencing in nonexpressing lineages, while promoters for genes expressed preferentially at later stages are often CG poor and primarily employ DNA methylation upon repression.

TL;DR: It is found that deletion of Tet2 causes extensive loss of 5hmC at enhancers, accompanied by enhancer hypermethylation, reduction of enhancer activity, and delayed gene induction in the early steps of differentiation.

TL;DR: The resulting large collection of haplotype-resolved epigenomic maps reveals extensive allelic biases in both chromatin state and transcription, which show considerable variation across tissues and between individuals, and allow us to investigate cis-regulatory relationships between genes and their control sequences.

TL;DR: Mice with exclusive expression of Tet1s failed to erase imprints in PGCs and displayed developmental defects in progeny, showing that isoform switch of TET1 regulates epigenetic memory erasure and mouse development.