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Nigel J. Mouncey
Researcher at United States Department of Energy
Publications - 6
Citations - 125
Nigel J. Mouncey is an academic researcher from United States Department of Energy. The author has contributed to research in topics: Service provider & Nexus (standard). The author has an hindex of 4, co-authored 6 publications receiving 58 citations. Previous affiliations of Nigel J. Mouncey include Lawrence Berkeley National Laboratory & Joint Genome Institute.
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Journal ArticleDOI
CRAGE enables rapid activation of biosynthetic gene clusters in undomesticated bacteria.
Gaoyan Wang,Zhiying Zhao,Jing Ke,Yvonne Engel,Yi-Ming Shi,David Robinson,Kerem Bingol,Zheyun Zhang,Benjamin P. Bowen,Benjamin P. Bowen,Katherine B. Louie,Bing Wang,Robert Evans,Yu Miyamoto,Kelly Cheng,Suzanne M. Kosina,Markus de Raad,Leslie P. Silva,Alicia Luhrs,Andrea Lubbe,David W. Hoyt,Charles Francavilla,Hiroshi Otani,Hiroshi Otani,Samuel Deutsch,Samuel Deutsch,Nancy M. Washton,Edward M. Rubin,Nigel J. Mouncey,Nigel J. Mouncey,Axel Visel,Axel Visel,Trent R. Northen,Trent R. Northen,Jan Fang Cheng,Jan Fang Cheng,Helge B. Bode,Yasuo Yoshikuni +37 more
TL;DR: Development of chassis-independent recombinase-assisted genome engineering (CRAGE) enables the integration of plasmids encoding biosynthetic gene clusters into the chromosomes of diverse bacteria to optimize production of natural products in non-native strains.
Journal ArticleDOI
Tiny Earth: A Big Idea for STEM Education and Antibiotic Discovery.
Amanda Hurley,Marc G. Chevrette,Deepa D. Acharya,Gabriel L. Lozano,Gabriel L. Lozano,Manuel F. Garavito,Jen Heinritz,Luis Balderrama,Luis Balderrama,Mara Beebe,Martel L. DenHartog,Kamiyah Corinaldi,Kamiyah Corinaldi,Renee Engels,Alyssa Gutierrez,Alyssa Gutierrez,Orli Jona,Josephine H. I. Putnam,Brody Rhodes,Brody Rhodes,Tiffany Tsang,Simon Hernandez,Carol A. Bascom-Slack,Jessamina E. Blum,Paul A. Price,Debra A. Davis,Joanna Klein,Joshua D. Pultorak,Nora L. Sullivan,Nigel J. Mouncey,Pieter C. Dorrestein,Sarah Miller,Nichole A. Broderick,Nichole A. Broderick,Jo Handelsman +34 more
Abstract: The world faces two seemingly unrelated challenges-a shortfall in the STEM workforce and increasing antibiotic resistance among bacterial pathogens. We address these two challenges with Tiny Earth, an undergraduate research course that excites students about science and creates a pipeline for antibiotic discovery.
Journal ArticleDOI
The emergence of microbiome centres.
Jennifer B. H. Martiny,Katrine Whiteson,Brendan J. M. Bohannan,Lawrence A. David,Nicole A. Hynson,Margaret J. McFall-Ngai,John F. Rawls,Thomas M. Schmidt,Zaid Abdo,Martin J. Blaser,Seth R. Bordenstein,Christian Bréchot,Carolee T. Bull,Pieter C. Dorrestein,Jonathan A. Eisen,Ferran Garcia-Pichel,Jack A. Gilbert,Kirsten S. Hofmockel,Mary L. Holtz,Rob Knight,David B. Mark Welch,Daniel McDonald,Barbara Methé,Nigel J. Mouncey,Noel T. Mueller,Catherine A. Pfister,Lita M. Proctor,Joel L. Sachs +27 more
TL;DR: A newly created network aims to share strategies and accelerate knowledge transfer, and invites others to join the efforts.
Posted ContentDOI
Tiny Earth: A Big Idea for STEM Education and Antibiotic Discovery
Amanda Hurley,Marc G. Chevrette,Deepa D. Acharya,Gabriel L. Lozano,Gabriel L. Lozano,Manuel F. Garavito,Jen Heinritz,Luis Balderrama,Luis Balderrama,Mara Beebe,Martel L. DenHartog,Kamiyah Corinaldi,Kamiyah Corinaldi,Renee Engels,Alyssa Gutierrez,Alyssa Gutierrez,Orli Jona,Josephine H. I. Putnam,Brody Rhodes,Brody Rhodes,Tiffany Tsang,Simon Hernandez,Carol A. Bascom-Slack,Jessamina E. Blum,Paul A. Price,Debra A. Davis,Joanna Klein,Joshua D. Pultorak,Nora L. Sullivan,Nigel J. Mouncey,Pieter C. Dorrestein,Sarah Miller,Nichole A. Broderick,Nichole A. Broderick,Jo Handelsman +34 more
TL;DR: Tiny Earth, an undergraduate research course that excites students about science and creates a pipeline for antibiotic discovery, addresses the world's shortfall in the STEM workforce and increasing antibiotic resistance among bacterial pathogens.
Journal ArticleDOI
New voyages to explore the natural product galaxy
TL;DR: There is a resurgence of activity in exploring natural products for a wide range of applications, due to not only increasing antibiotic resistance, but the advent of next-generation genome sequencing and new technologies to interrogate and investigate natural product biosynthesis.