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Nigel Skinner
Researcher at Agilent Technologies
Publications - 6
Citations - 467
Nigel Skinner is an academic researcher from Agilent Technologies. The author has contributed to research in topics: Context (language use) & Epigenome. The author has an hindex of 5, co-authored 6 publications receiving 416 citations.
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Journal ArticleDOI
A roadmap for the development of alternative (non-animal) methods for systemic toxicity testing.
David A. Basketter,Harvey J. Clewell,Ian Kimber,Annamaria Rossi,Bas J. Blaauboer,Robert Burrier,Mardas Daneshian,Chantra Eskes,Alan M. Goldberg,Nina Hasiwa,Sebastian Hoffmann,Joanna Jaworska,Thomas B. Knudsen,Robert Landsiedel,Marcel Leist,Paul A. Locke,Gavin Maxwell,James M. McKim,Emily A. McVey,Gladys Ouedraogo,Grace Patlewicz,Olavi Pelkonen,Erwin Ludo Roggen,Costanza Rovida,Irmela Ruhdel,Michael Schwarz,Andreas Schepky,Greet Schoeters,Nigel Skinner,Kerstin Trentz,Marian Turner,Philippe Vanparys,James D. Yager,Joanne Zurlo,Thomas Hartung +34 more
TL;DR: In this paper, the authors present a roadmap for how to overcome the acknowledged scientific gaps for the full replacement of systemic toxicity testing using animals, which is a major concern for the current state of the art.
Journal ArticleDOI
Metabolomics in Toxicology and Preclinical Research
Tzutzuy Ramirez,Mardas Daneshian,Hennicke Kamp,Frédéric Y. Bois,Malcolm R. Clench,Muireann Coen,Beth Donley,Steven M. Fischer,Drew R. Ekman,Eric Fabian,Claude Guillou,Joachim Heuer,Helena T. Hogberg,Harald Jungnickel,Hector C. Keun,G. Krennrich,Eckart Krupp,Andreas Luch,Fozia Noor,Erik Peter,Bjoern Riefke,Mark Seymour,Nigel Skinner,Lena Smirnova,Elwin Verheij,Silvia Wagner,Thomas Hartung,Bennard van Ravenzwaay,Marcel Leist +28 more
TL;DR: Three working groups addressing questions regarding 1) metabolomics for in vitro studies 2) the appropriate use of metabolomics in systems toxicology, and 3) use of metabolites in a regulatory context are addressed.
Food for Thought … Systems Toxicology
TL;DR: A "systems toxicology" approach will enable virtual experiments to be conducted that can improve the prediction of hazard and the assessment of compound toxicity.
Journal ArticleDOI
3D-DIP-Chip: a microarray-based method to measure genomic DNA damage
James Powell,Mark Bennett,Katie Ellen Evans,Shirong Yu,Richard Webster,Raymond Waters,Nigel Skinner,Simon H. Reed +7 more
TL;DR: 3D-DIP-Chip is developed, a microarray-based method to measure the prevalence of genomic genotoxin-induced DNA damage, and it is demonstrated the measurement of both physical and chemical induced DNA damage spectra.
Journal ArticleDOI
Functional genome-wide analysis: a technical review, its developments and its relevance to cancer research.
TL;DR: The historical context of this technology is reviewed and current and future perspectives on how this technique is currently being developed and modified to allow its use in novel areas of research are offered.