O
Odetta Antico
Researcher at University of Dundee
Publications - 10
Citations - 193
Odetta Antico is an academic researcher from University of Dundee. The author has contributed to research in topics: Ubiquitin & Ubiquitin ligase. The author has an hindex of 3, co-authored 7 publications receiving 76 citations.
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Journal ArticleDOI
Phosphorylation of Parkin at serine 65 is essential for its activation in vivo.
Thomas G. McWilliams,Thomas G. McWilliams,Erica Barini,Risto Pohjolan-Pirhonen,Simon Philip Brooks,François Singh,Sophie Burel,Kristin Balk,Atul Kumar,Lambert Montava-Garriga,Alan R. Prescott,Sidi Mohamed Hassoun,François Mouton-Liger,Graeme Ball,Rachel Hills,Axel Knebel,Ayse Ulusoy,Donato A. Di Monte,Jevgenia Tamjar,Odetta Antico,Kyle Fears,Laura Smith,Riccardo Brambilla,Eino Palin,Miko Valori,Johanna Eerola-Rautio,Pentti J. Tienari,Olga Corti,Stephen B. Dunnett,Ian G. Ganley,Anu Suomalainen,Miratul M. K. Muqit +31 more
TL;DR: The clinical relevance of the findings is substantiated by the discovery of homozygous PARKIN (PARK2) p.S65N mutations in two unrelated patients with PD and biochemical and structural analysis demonstrates that the ParkinS 65N/S65n mutant is pathogenic and cannot be activated by PINK1.
Journal ArticleDOI
Deubiquitinating enzyme amino acid profiling reveals a class of ubiquitin esterases.
Virginia De Cesare,Daniel Carbajo Lopez,Peter D. Mabbitt,Adam J. Fletcher,Mathieu Soetens,Odetta Antico,Nicola T. Wood,Satpal Virdee +7 more
TL;DR: In this article, a mass spectrometry-based deubiquitinating enzyme (DUB) assay was used to investigate the role of non-lysine ubiquitination.
Journal ArticleDOI
Functional Diversification of SRSF Protein Kinase to Control Ubiquitin-Dependent Neurodevelopmental Signaling
Francisco Bustos,Anna Segarra-Fas,Gino Nardocci,Andrew Cassidy,Odetta Antico,Lindsay Davidson,Lennart Brandenburg,Thomas Macartney,Rachel Toth,C. James Hastie,Jennifer Moran,Robert Gourlay,Joby Varghese,Renata F. Soares,Martin Montecino,Greg M. Findlay +15 more
TL;DR: Surprisingly, it is shown that SRPK has acquired the capacity to control a neurodevelopmental ubiquitin signaling pathway, and unappreciated functional diversification of SRPK is revealed to regulate ubiquit in signaling that ensures correct regulation of neuro developmental gene expression.
Posted ContentDOI
Deubiquitinating Enzyme Amino Acid Profiling Reveals a Class of Ubiquitin Esterases
Virginia De Cesare,Daniel Carbajo Lopez,Peter D. Mabbitt,Odetta Antico,Nicola T. Wood,Satpal Virdee +5 more
TL;DR: The Machado Josephin Domain (MJD) class is found to be unappreciated non-lysine DUBs with highly specific ubiquitin esterase activity that rivals the efficiency of the most active isopeptidases.
Journal ArticleDOI
Global ubiquitylation analysis of mitochondria in primary neurons identifies endogenous Parkin targets following activation of PINK1.
Odetta Antico,Alban Ordureau,Michael Stevens,François Singh,Raja Sekhar Nirujogi,Marek Gierlinski,Erica Barini,Mollie L. Rickwood,Alan R. Prescott,Rachel Toth,Ian G. Ganley,J. Wade Harper,Miratul M. K. Muqit +12 more
TL;DR: In this paper, a proteomic analysis of mitochondria from mouse neurons was performed to identify ubiquitylated substrates of endogenous Parkin, and the results revealed a subset of 49 PINK1 activation-dependent diGLY sites.