Functional Diversification of SRSF Protein Kinase to Control Ubiquitin-Dependent Neurodevelopmental Signaling
Francisco Bustos,Anna Segarra-Fas,Gino Nardocci,Andrew Cassidy,Odetta Antico,Lindsay Davidson,Lennart Brandenburg,Thomas Macartney,Rachel Toth,C. James Hastie,Jennifer Moran,Robert Gourlay,Joby Varghese,Renata F. Soares,Martin Montecino,Greg M. Findlay +15 more
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TLDR
Surprisingly, it is shown that SRPK has acquired the capacity to control a neurodevelopmental ubiquitin signaling pathway, and unappreciated functional diversification of SRPK is revealed to regulate ubiquit in signaling that ensures correct regulation of neuro developmental gene expression.About:
This article is published in Developmental Cell.The article was published on 2020-12-07 and is currently open access. It has received 27 citations till now. The article focuses on the topics: Ubiquitin ligase & Ubiquitin.read more
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Noncanonical functions of the serine-arginine-rich splicing factor (SR) family of proteins in development and disease.
Rebecca E Wagner,Michaela Frye +1 more
TL;DR: The serine/arginine (SR)-rich protein family of splicing factors play versatile roles in RNA processing steps and are often essential for normal development as discussed by the authors, however, their misregulation contributes to human diseases such as cancer.
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Oncogenic dysregulation of pre-mRNA processing by protein kinases: challenges and therapeutic opportunities.
TL;DR: In this paper, the authors describe key findings that have been reported on these topics and discuss challenges and opportunities of developing therapeutic approaches targeting splicing factor kinases, and discuss the potential of using these kinases for drug development.
Journal Article
SRPK2 Phosphorylates Tau and Mediates the Cognitive Defects in Alzheimer's Disease
Yi Hong,Chi Bun Chan,Il Sun Kwon,Xuekun Li,Mingke Song,Hyun Pil Lee,Xia Liu,Pradoldej Sompol,Peng Jin,Hyoung Gon Lee,Shan Ping Yu,Keqiang Ye +11 more
TL;DR: Zhang et al. as mentioned in this paper showed that SRPK2 phosphorylates tau on S214, suppresses tau-dependent microtubule polymerization, and inhibits axonal elongation in neurons.
Journal ArticleDOI
Good Cop, Bad Cop: The Different Roles of SRPKs
TL;DR: Specific cell states coupled to kinase levels, spatial specific interactions with substrates but also changes in the extent of phosphorylation that allow SR PKs to exhibit a rheostat-like control on their substrates could decide the proliferative or antiproliferative role of SRPKs.
Journal ArticleDOI
RNF12 is regulated by AKT phosphorylation and promotes TGF-β driven breast cancer metastasis
Yongsheng Huang,Sijia Liu,Mengjie Shan,Sophie C. Hagenaars,Wilma E. Mesker,Danielle Cohen,Lin Wang,Zhi Zheng,Peter Devilee,R.A.E.M. Tollenaar,Zhangfu Li,Yongmei Song,Yong Zhang,Duan Li,Peter ten Dijke +14 more
TL;DR: In this paper , RNF12 was found to be an important determinant in the crosstalk between the TGF-β and AKT signaling pathways during breast cancer progression.
References
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