J
Jyoti Khadake
Researcher at Cambridge University Hospitals NHS Foundation Trust
Publications - 21
Citations - 4110
Jyoti Khadake is an academic researcher from Cambridge University Hospitals NHS Foundation Trust. The author has contributed to research in topics: Histone H1 & Histone octamer. The author has an hindex of 14, co-authored 21 publications receiving 3621 citations. Previous affiliations of Jyoti Khadake include European Bioinformatics Institute & Jawaharlal Nehru Centre for Advanced Scientific Research.
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Journal ArticleDOI
The MIntAct project--IntAct as a common curation platform for 11 molecular interaction databases.
Sandra Orchard,Mais G. Ammari,Bruno Aranda,Lionel Breuza,Leonardo Briganti,Fiona Broackes-Carter,Nancy H. Campbell,Gayatri Chavali,Carol Chen,Noemi del-Toro,Margaret Duesbury,Marine Dumousseau,Eugenia Galeota,Ursula Hinz,Marta Iannuccelli,Sruthi Jagannathan,Rafael C. Jimenez,Jyoti Khadake,Astrid Lagreid,Luana Licata,Ruth C. Lovering,Birgit H M Meldal,Anna N. Melidoni,Mila Milagros,Daniele Peluso,Livia Perfetto,Pablo Porras,Arathi Raghunath,Sylvie Ricard-Blum,Bernd Roechert,Andre Stutz,Michael Tognolli,Kim Van Roey,Gianni Cesareni,Henning Hermjakob +34 more
TL;DR: All data manually curated by the MINT curators have been moved into the IntAct database at EMBL-EBI and are merged with the existing IntAct dataset.
Journal ArticleDOI
IntAct—open source resource for molecular interaction data
Samuel Kerrien,Yasmin Alam-Faruque,Bruno Aranda,I. Bancarz,Alan Bridge,C. Derow,Emily Dimmer,Marc Feuermann,A. Friedrichsen,Rachael P. Huntley,C. Kohler,Jyoti Khadake,Catherine Leroy,A. Liban,C. Lieftink,Luisa Montecchi-Palazzi,Sandra Orchard,Judith Risse,Karine Robbe,Bernd Roechert,David Thorneycroft,Y. Zhang,Rolf Apweiler,Henning Hermjakob +23 more
TL;DR: IntAct is an open source database and software suite for modeling, storing and analyzing molecular interaction data that features over 126 000 binary interactions extracted from over 2100 scientific publications and makes extensive use of controlled vocabularies.
Journal ArticleDOI
Protein interaction data curation: the International Molecular Exchange (IMEx) consortium
Sandra Orchard,Samuel Kerrien,Sara Abbani,Bruno Aranda,Jignesh Bhate,Shelby L. Bidwell,Alan Bridge,Leonardo Briganti,Fiona S. L. Brinkman,Gianni Cesareni,Andrew Chatr-aryamontri,Andrew Chatr-aryamontri,Emilie Chautard,Emilie Chautard,Carol Chen,Marine Dumousseau,Johannes B. Goll,Robert E. W. Hancock,Linda Hannick,Igor Jurisica,Jyoti Khadake,David J. Lynn,Usha Mahadevan,Livia Perfetto,Arathi Raghunath,Sylvie Ricard-Blum,Bernd Roechert,Lukasz Salwinski,Volker Stümpflen,Mike Tyers,Mike Tyers,Peter Uetz,Ioannis Xenarios,Ioannis Xenarios,Henning Hermjakob +34 more
TL;DR: The International Molecular Exchange consortium is an international collaboration between major public interaction data providers to share literature-curation efforts and make a nonredundant set of protein interactions available in a single search interface on a common website.
Journal ArticleDOI
New gene functions in megakaryopoiesis and platelet formation
Christian Gieger,Aparna Radhakrishnan,Ana Cvejic,Weihong Tang,Eleonora Porcu,Giorgio Pistis,Jovana Serbanovic-Canic,Ulrich Elling,Alison H. Goodall,Yann Labrune,Lorna M. Lopez,Reedik Mägi,Stuart Meacham,Yukinori Okada,Nicola Pirastu,Rossella Sorice,Alexander Teumer,Katrin Voss,Weihua Zhang,Ramiro Ramirez-Solis,Joshua C. Bis,David Ellinghaus,Martin Gögele,Jouke-Jan Hottenga,Claudia Langenberg,Peter Kovacs,Paul F. O'Reilly,So Youn Shin,Tõnu Esko,Jaana Hartiala,Stavroula Kanoni,Federico Murgia,Afshin Parsa,Jonathan Stephens,Pim van der Harst,C. Ellen van der Schoot,Hooman Allayee,Antony P. Attwood,Beverley Balkau,François Bastardot,Saonli Basu,Sebastian E. Baumeister,Ginevra Biino,Lorenzo Bomba,Amélie Bonnefond,François Cambien,John C. Chambers,Francesco Cucca,Pio D'Adamo,Gail Davies,Rudolf A. de Boer,Eco J. C. de Geus,Angela Döring,Paul Elliott,Jeanette Erdmann,David M. Evans,Mario Falchi,Wei Feng,Aaron R. Folsom,Ian H. Frazer,Quince Gibson,Nicole L. Glazer,Christopher J Hammond,Anna-Liisa Hartikainen,Susan R. Heckbert,Christian Hengstenberg,Micha Hersch,Thomas Illig,Ruth J. F. Loos,Jennifer Jolley,Kay-Tee Khaw,Brigitte Kühnel,Marie-Christine Kyrtsonis,Vasiliki Lagou,Heather Lloyd-Jones,Thomas Lumley,Massimo Mangino,Andrea Maschio,Irene Mateo Leach,Barbara McKnight,Yasin Memari,Braxton D. Mitchell,Grant W. Montgomery,Yusuke Nakamura,Matthias Nauck,Gerjan Navis,Ute Nöthlings,Ilja M. Nolte,David J. Porteous,Anneli Pouta,Peter P. Pramstaller,Janne Pullat,Susan M. Ring,Jerome I. Rotter,Daniela Ruggiero,Aimo Ruokonen,Cinzia Sala,Nilesh J. Samani,Jennifer G. Sambrook,David Schlessinger,Stefan Schreiber,Heribert Schunkert,James Scott,Nicholas L. Smith,Harold Snieder,John M. Starr,Michael Stumvoll,Atsushi Takahashi,W.H. Wilson Tang,Kent D. Taylor,Albert Tenesa,Swee Lay Thein,Anke Tönjes,Manuela Uda,Sheila Ulivi,Dirk J. van Veldhuisen,Peter M. Visscher,Uwe Völker,H.-Erich Wichmann,Kerri L. Wiggins,Gonneke Willemsen,Tsun-Po Yang,Jing Hua Zhao,Paavo Zitting,John Bradley,George Dedoussis,Paolo Gasparini,Stanley L. Hazen,Andres Metspalu,Mario Pirastu,Alan R. Shuldiner,L. Joost van Pelt,Jaap Jan Zwaginga,Dorret I. Boomsma,Ian J. Deary,Andre Franke,Philippe Froguel,Santhi K. Ganesh,Marjo-Riitta Järvelin,Nicholas G. Martin,Christa Meisinger,Bruce M. Psaty,Tim D. Spector,Nicholas J. Wareham,Jan Willem N. Akkerman,Marina Ciullo,Panos Deloukas,Andreas Greinacher,Steve Jupe,Naoyuki Kamatani,Jyoti Khadake,Jaspal S. Kooner,Josef M. Penninger,Inga Prokopenko,Derek L. Stemple,Daniela Toniolo,Lorenz Wernisch,Serena Sanna,Andrew A. Hicks,Augusto Rendon,Manuel A. R. Ferreira,Willem H. Ouwehand,Nicole Soranzo +162 more
TL;DR: A high-powered meta-analysis of genome-wide association studies (GWAS) in up to 66,867 individuals of European ancestry is carried out, identifying 68 genomic loci reliably associated with platelet count and volume mapping to established and putative novel regulators of megakaryopoiesis and platelet formation.
Journal ArticleDOI
PSICQUIC and PSISCORE: accessing and scoring molecular interactions
Bruno Aranda,Hagen Blankenburg,Samuel Kerrien,Fiona S. L. Brinkman,Arnaud Ceol,Emilie Chautard,Jose M. Dana,Javier De Las Rivas,Marine Dumousseau,Eugenia Galeota,Anna Gaulton,Johannes B. Goll,Robert E. W. Hancock,Ruth Isserlin,Rafael C. Jimenez,Jules Kerssemakers,Jyoti Khadake,David J. Lynn,Magali Michaut,Gavin O'Kelly,Keiichiro Ono,Sandra Orchard,Carlos Prieto,Sabry Razick,Olga Rigina,Lukasz Salwinski,Milan Simonovic,Sameer Velankar,Andrew G. Winter,Guanming Wu,Gary D. Bader,Gianni Cesareni,Ian Donaldson,David Eisenberg,Gerard J. Kleywegt,John P. Overington,Sylvie Ricard-Blum,Mike Tyers,Mario Albrecht,Henning Hermjakob +39 more
TL;DR: To study proteins in the context of a cellular system, it is essential that the molecules with which a protein interacts are identified and the functional consequence of each interaction is understood.