G
Gail Charnley
Researcher at Massachusetts Institute of Technology
Publications - 18
Citations - 2000
Gail Charnley is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: Risk assessment & Environmental exposure. The author has an hindex of 11, co-authored 18 publications receiving 1860 citations. Previous affiliations of Gail Charnley include Boston University.
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Journal ArticleDOI
Toxicity testing in the 21st century: a vision and a strategy
Daniel Krewski,Daniel Acosta,Melvin E. Andersen,Henry A. Anderson,John C. Bailar,Kim Boekelheide,Robert L. Brent,Gail Charnley,Vivian G. Cheung,Sidney Green,Karl T. Kelsey,Nancy I. Kerkvliet,Abby A. Li,Lawrence E. McCray,Otto A. Meyer,Reid D. Patterson,William D. Pennie,Robert A. Scala,Gina Solomon,Martin L. Stephens,James D. Yager,Lauren Zeise +21 more
TL;DR: Implementation of a new toxicity testing paradigm firmly based on human biology by transitioning from current expensive and lengthy in vivo testing with qualitative endpoints to in vitro toxicity pathway assays on human cells or cell lines using robotic high-throughput screening with mechanistic quantitative parameters.
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A comprehensive evaluation of the potential health risks associated with occupational and environmental exposure to styrene.
Joshua T. Cohen,Gary P. Carlson,Gail Charnley,David Coggon,Elizabeth Delzell,John D. Graham,Helmut Greim,Daniel Krewski,Michele A. Medinsky,Richard R. Monson,Dennis J. Paustenbach,Barbara Petersen,Stephen M. Rappaport,Lorenz Rhomberg,P. Barry Ryan,Kimberly M. Thompson +15 more
TL;DR: This study highlights the importance of knowing the carrier and removal status of canine coronavirus, as a source of infection for other animals, not necessarily belonging to the same breeds.
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Biologically motivated cancer risk models
TL;DR: A two-stage dose response model is proposed for use in cancer risk assessment that assumes that transformation probabilities and cellular dynamics are exposure- and time-dependent.
Journal Article
Flow Cytometric Analysis of the Effect of Sodium Chloride on Gastric Cancer Risk in the Rat
TL;DR: The hypothesis that salt enhances gastric cancer risk from N-methyl-N'-nitro-N-nitrosoguanidine by disruption of the "mucosal barrier" leading to an increased effective dose to target cells is not supported by the results of these experiments.
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Symposium summary: children's health risk--what's so special about the developing immune system?
Michael P. Holsapple,Dennis J. Paustenbach,Gail Charnley,Lori J. West,Michael I. Luster,Rodney R. Dietert,Leigh Ann Burns-Naas +6 more
TL;DR: A risk-based evaluation of the biology associated with the proposed differential sensitivity between children and adults and the impact of that assessment on additional regulatory measures to protect children in risk assessment analyses is needed.