P
P. Pearl O'Rourke
Researcher at Partners HealthCare
Publications - 42
Citations - 1944
P. Pearl O'Rourke is an academic researcher from Partners HealthCare. The author has contributed to research in topics: Extracorporeal membrane oxygenation & Congenital diaphragmatic hernia. The author has an hindex of 20, co-authored 39 publications receiving 1856 citations. Previous affiliations of P. Pearl O'Rourke include Harvard University & University of Washington.
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Journal ArticleDOI
Extracorporeal membrane oxygenation and conventional medical therapy in neonates with persistent pulmonary hypertension of the newborn: a prospective randomized study.
P. Pearl O'Rourke,Robert K. Crone,Joseph P. Vacanti,James H. Ware,Craig W. Lillehei,Richard B. Parad,Michael F. Epstein +6 more
TL;DR: Thirty-nine newborn infants with severe persistent pulmonary hypertension and respiratory failure who met criteria for 85% likelihood of dying were enrolled in a randomized trial in which extracorporeal membrane oxygenation (ECMO) therapy was compared with conventional medical therapy (CMT).
Journal ArticleDOI
Global implementation of genomic medicine: We are not alone
Teri A. Manolio,Marc Abramowicz,Fahd Al-Mulla,Warwick P Anderson,Rudi Balling,Adam C. Berger,Steven B. Bleyl,Aravinda Chakravarti,Wasun Chantratita,Rex L. Chisholm,Vajira H. W. Dissanayake,Michael Dunn,Victor J. Dzau,Bok-Ghee Han,Tim Hubbard,Anne Kolbe,Bruce R. Korf,Michiaki Kubo,Paul Lasko,Erkki Leego,Surakameth Mahasirimongkol,Partha P. Majumdar,Gert Matthijs,Howard L. McLeod,Andres Metspalu,Pierre Meulien,Satoru Miyano,Yaakov Naparstek,P. Pearl O'Rourke,George P. Patrinos,Heidi L. Rehm,Mary V. Relling,Gad Rennert,Laura Lyman Rodriguez,Dan M. Roden,Alan R. Shuldiner,Sukdeb Sinha,Patrick Tan,Mats Ulfendahl,Robyn L. Ward,Marc S. Williams,John Wong,Eric D. Green,Geoffrey S. Ginsburg +43 more
TL;DR: Efforts to coalesce human-genomics groups around concrete but compelling signature projects should accelerate the responsible implementation of genomic medicine in efforts to improve clinical care worldwide.
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Fetal diaphragmatic hernia: Ultrasound diagnosis and clinical outcome in 38 cases
N. Scott Adzick,Joseph P. Vacanti,Craig W. Lillehei,P. Pearl O'Rourke,Robert K. Crone,Jay M. Wilson +5 more
TL;DR: Improved postnatal therapy or surgical intervention before birth will be necessary to salvage the CDH fetus with an early gestational diagnosis or associated polyhydramnios.
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Framework for development of physician competencies in genomic medicine: report of the Competencies Working Group of the Inter-Society Coordinating Committee for Physician Education in Genomics
Bruce R. Korf,Anna B. Berry,Melvin Limson,Ali J. Marian,Michael F. Murray,P. Pearl O'Rourke,Eugene R. Passamani,Mary V. Relling,John F. Tooker,Gregory J. Tsongalis,Laura Lyman Rodriguez +10 more
TL;DR: The National Human Genome Research Institute has convened the Inter-Society Coordinating Committee for Physician Education in Genomics (ISCC) to develop and share best practices in the use of genomics in medicine.
Journal ArticleDOI
Delayed repair and preoperative ECMO does not improve survival in high-risk congenital diaphragmatic hernia.
TL;DR: Survivors in the delayed repair group were ventilated longer and on ECMO longer, but had fewer late deaths and fewer pulmonary sequelae (O2 dependency at discharge) than infants in the immediate repair group (P less than .05).