P
Pall I. Olason
Researcher at deCODE genetics
Publications - 14
Citations - 4407
Pall I. Olason is an academic researcher from deCODE genetics. The author has contributed to research in topics: Population & Genome-wide association study. The author has an hindex of 7, co-authored 11 publications receiving 4082 citations. Previous affiliations of Pall I. Olason include Amgen.
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Journal ArticleDOI
Common variants conferring risk of schizophrenia
Hreinn Stefansson,Hreinn Stefansson,Roel A. Ophoff,Roel A. Ophoff,Roel A. Ophoff,Stacy Steinberg,Stacy Steinberg,Ole A. Andreassen,Sven Cichon,Dan Rujescu,Thomas Werge,Olli Pietilainen,Ole Mors,Preben Bo Mortensen,Engilbert Sigurdsson,Omar Gustafsson,Mette Nyegaard,Annamari Tuulio-Henriksson,Andres Ingason,Thomas Hansen,Jaana Suvisaari,Jouko Lönnqvist,Tiina Paunio,Anders D. Børglum,Anders D. Børglum,Annette M. Hartmann,Anders Fink-Jensen,Merete Nordentoft,David M. Hougaard,Bent Nørgaard-Pedersen,Yvonne Böttcher,Jes Olesen,René Breuer,Hans-Jürgen Möller,Ina Giegling,Henrik B. Rasmussen,Sally Timm,Manuel Mattheisen,István Bitter,János Réthelyi,Brynja B. Magnusdottir,Thordur Sigmundsson,Pall I. Olason,Gisli Masson,Jeffrey R. Gulcher,Magnús Haraldsson,Ragnheidur Fossdal,Thorgeir E. Thorgeirsson,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,Mirella Ruggeri,Sarah Tosato,Barbara Franke,Eric Strengman,Lambertus A. Kiemeney,Ingrid Melle,Srdjan Djurovic,Lilia I. Abramova,Kaleda Vg,Julio Sanjuán,Rosa de Frutos,Elvira Bramon,Evangelos Vassos,Gillian Fraser,Ulrich Ettinger,Marco Picchioni,Nicholas Walker,T. Toulopoulou,Anna C. Need,Dongliang Ge,Joeng Lim Yoon,Kevin V. Shianna,Nelson B. Freimer,Rita M. Cantor,Robin M. Murray,Augustine Kong,Vera Golimbet,Angel Carracedo,Celso Arango,Javier Costas,Erik G. Jönsson,Lars Terenius,Ingrid Agartz,Hannes Petursson,Markus M. Nöthen,Marcella Rietschel,Paul M. Matthews,Pierandrea Muglia,Leena Peltonen,David St Clair,David Goldstein,Kari Stefansson,Kari Stefansson,David A. Collier,David A. Collier +94 more
TL;DR: Findings implicating the MHC region are consistent with an immune component to schizophrenia risk, whereas the association with NRGN and TCF4 points to perturbation of pathways involved in brain development, memory and cognition.
Journal ArticleDOI
De Novo CNV Analysis Implicates Specific Abnormalities of Postsynaptic Signalling Complexes in the Pathogenesis of Schizophrenia
George Kirov,Andrew Pocklington,Peter Holmans,Dobril Ivanov,Masashi Ikeda,Douglas M. Ruderfer,Douglas M. Ruderfer,Jennifer L. Moran,Kimberly Chambert,Draga Toncheva,Lyudmila Georgieva,Detelina Grozeva,Marija Fjodorova,Rebecca Louise Wollerton,Elliott Rees,Ivan Nikolov,L N van de Lagemaat,Àlex Bayés,Esperanza Fernández,Pall I. Olason,Yvonne Böttcher,Noboru H. Komiyama,Mark O. Collins,Jyoti S. Choudhary,Kari Stefansson,Hreinn Stefansson,Seth G. N. Grant,Shaun Purcell,Shaun Purcell,Pamela Sklar,Pamela Sklar,Michael Conlon O'Donovan,Michael John Owen +32 more
TL;DR: The data indicate that defects in NMDAR postsynaptic signalling and, possibly, ARC complexes, which are known to be important in synaptic plasticity and cognition, play a significant role in the pathogenesis of schizophrenia.
Journal ArticleDOI
Parental origin of sequence variants associated with complex diseases
Augustine Kong,Valgerdur Steinthorsdottir,Gisli Masson,Gudmar Thorleifsson,Patrick Sulem,Søren Besenbacher,Aslaug Jonasdottir,Asgeir Sigurdsson,Kari T. Kristinsson,Adalbjorg Jonasdottir,Michael L. Frigge,Arnaldur Gylfason,Pall I. Olason,Sigurjon A. Gudjonsson,Sverrir T. Sverrisson,Simon N. Stacey,Bardur Sigurgeirsson,Kristrun R. Benediktsdottir,Helgi Sigurdsson,Thorvaldur Jonsson,Rafn Benediktsson,Jón Ólafsson,Oskar T. Johannsson,Astradur B. Hreidarsson,Gunnar Sigurdsson,Anne C. Ferguson-Smith,Daniel F. Gudbjartsson,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,Kari Stefansson,Kari Stefansson +30 more
TL;DR: It is shown that for 38,167 Icelanders genotyped using single nucleotide polymorphism (SNP) chips, the parental origin of most alleles can be determined and a novel association between the SNP rs2334499 at 11p15 and type 2 diabetes is observed.
Journal ArticleDOI
Disruption of the neurexin 1 gene is associated with schizophrenia
Dan Rujescu,Andres Ingason,Andres Ingason,Sven Cichon,Olli Pietiläinen,Michael R. Barnes,Timothea Toulopoulou,Marco Picchioni,Evangelos Vassos,Ulrich Ettinger,Elvira Bramon,Robin M. Murray,Mirella Ruggeri,Sarah Tosato,Chiara Bonetto,Stacy Steinberg,Engilbert Sigurdsson,Thordur Sigmundsson,Hannes Petursson,Arnaldur Gylfason,Pall I. Olason,Gudmundur Hardarsson,Gudrun A. Jonsdottir,Omar Gustafsson,Ragnheidur Fossdal,Ina Giegling,Hans-Jürgen Möller,Annette M. Hartmann,Per Hoffmann,Caroline Crombie,Gillian Fraser,Nicholas Walker,Jouko Lönnqvist,Jaana Suvisaari,Annamari Tuulio-Henriksson,Srdjan Djurovic,Ingrid Melle,Ole A. Andreassen,Thomas Hansen,Thomas Werge,Lambertus A. Kiemeney,Barbara Franke,Joris A. Veltman,Jacobine E. Buizer-Voskamp,Chiara Sabatti,Roel A. Ophoff,Marcella Rietschel,Markus M. Nöthen,K. Stefansson,Leena Peltonen,David St Clair,Hreinn Stefansson,David A. Collier +52 more
TL;DR: It is concluded that NRXN1 deletions affecting exons confer risk of schizophrenia.
Journal ArticleDOI
Detection of sharing by descent, long-range phasing and haplotype imputation
Augustine Kong,Gisli Masson,Michael L. Frigge,Arnaldur Gylfason,Pasha Zusmanovich,Gudmar Thorleifsson,Pall I. Olason,Andres Ingason,Stacy Steinberg,Thorunn Rafnar,Patrick Sulem,Magali Mouy,Frosti Jonsson,Unnur Thorsteinsdottir,Daniel F. Gudbjartsson,Hreinn Stefansson,Kari Stefansson +16 more
TL;DR: This work shows how to phase more than 1,000 SNPs simultaneously for a large fraction of the 35,528 Icelanders genotyped by Illumina chips, which is particularly powerful in studies of the inheritance of recurrent mutations and fine-scale recombinations in large sample sets.