Lilia I. Abramova

TL;DR: Findings implicating the MHC region are consistent with an immune component to schizophrenia risk, whereas the association with NRGN and TCF4 points to perturbation of pathways involved in brain development, memory and cognition.

TL;DR: Results from the largest BD GWAS to date are presented by investigating 2.3 million single-nucleotide polymorphisms (SNPs) in a sample of 24,025 patients and controls and detecting 56 genome-wide significant SNPs in five chromosomal regions including previously reported risk loci ANK3, ODZ4 and TRANK1.

TL;DR: Evidence is provided that NCAN encodes neurocan, an extracellular matrix glycoprotein, which is thought to be involved in cell adhesion and migration, and expression in mice is localized within cortical and hippocampal areas.

TL;DR: An expanded set of variants in the major histocompatibility complex region, near neurogranin (NRGN) and in an intron of transcription factor 4 (TCF4), and two novel variants showing genome-wide significant association are found.

TL;DR: As it has been proposed that variants such as rs1344706[T]—common and with low relative risk—may also serve to identify regions harboring less common, higher-risk susceptibility alleles, ZNF804A is searched for large copy number variants (CNVs) in psychosis patients and patients with other psychiatric disorders and 39 481 controls.