P
Pamela F. Jones
Researcher at Regeneron
Publications - 18
Citations - 12135
Pamela F. Jones is an academic researcher from Regeneron. The author has contributed to research in topics: Receptor tyrosine kinase & Angiopoietin. The author has an hindex of 14, co-authored 18 publications receiving 11784 citations. Previous affiliations of Pamela F. Jones include Beth Israel Deaconess Medical Center.
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Journal ArticleDOI
Angiopoietin-2, a Natural Antagonist for Tie2 That Disrupts in vivo Angiogenesis
Maisonpierre Peter C,Chitra Suri,Pamela F. Jones,Sona Bartunkova,Stanley J. Wiegand,Czeslaw Radziejewski,Debra L Compton,Joyce Mcclain,Aldrich Thomas H,Nick Papadopoulos,Thomas J. Daly,Samuel Davis,Thomas N. Sato,George D. Yancopoulos +13 more
TL;DR: The discovery of a negative regulator acting on Tie2 emphasizes the need for exquisite regulation of this angiogenic receptor system.
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Requisite Role of Angiopoietin-1, a Ligand for the TIE2 Receptor, during Embryonic Angiogenesis
Chitra Suri,Pamela F. Jones,Sybill Patan,Sona Bartunkova,Maisonpierre Peter C,Samuel Davis,Thomas N. Sato,George D. Yancopoulos +7 more
TL;DR: It is shown that mice engineered to lack Angiopoietin-1 display angiogenic deficits reminiscent of those previously seen in mice lacking TIE2, demonstrating that AngiopOietIn-1 is a primary physiologic ligand for TIE1 and that it has critical in vivo angiogenesis actions that are distinct from VEGF and that are not reflected in the classic in vitro assays used to characterize VEGf.
Journal ArticleDOI
Isolation of Angiopoietin-1, a Ligand for the TIE2 Receptor, by Secretion-Trap Expression Cloning
Samuel Davis,Aldrich Thomas H,Pamela F. Jones,Ann Acheson,Debra L Compton,Vivek Jain,Terence E Ryan,Joanne Bruno,Czeslaw Radziejewski,Maisonpierre Peter C,George D. Yancopoulos +10 more
TL;DR: The identification of a secreted ligand for TIE2, termed Angiopoietin-1, is reported using a novel expression cloning technique that involves intracellular trapping and detection of the ligand in COS cells.
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The anticoagulation factor protein S and its relative, Gas6, are ligands for the Tyro 3/Axl family of receptor tyrosine kinases
Trevor Stitt,Greg Conn,Martin Goret,Martin Goret,Cary Lai,Joanne Bruno,Czeslaw Radzlejewski,Karen Mattsson,John Fisher,David R. Gies,Pamela F. Jones,Piotr Masiakowski,Terence E Ryan,Nancy J Tobkes,D.H Chen,Peter S. DiStefano,George L. Long,Claudio Basilico,Mitchell Goldfarb,Greg Lemke,David J. Glass,George D. Yancopoulos +21 more
TL;DR: The identification of ligands for Tyro 3 and Axl (alternatively, Ark or UFO), members of a previously orphan family of receptor-like tyrosine kinases, correspond to protein S, a protease regulator that is a potent anticoagulant, and Gas6, a protein related toprotein S but lacking any known function.
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Mammalian neurotrophin-4: structure, chromosomal localization, tissue distribution, and receptor specificity.
Nancy Y. Ip,Carlos F. Ibáñez,Steven H. Nye,Joyce McClain,Pamela F. Jones,David R. Gies,Leonardo Belluscio,M M Le Beau,R. Espinosa,Stephen P. Squinto +9 more
TL;DR: A neurotrophin is isolated from both human and rat genomic DNA that appears to represent the mammalian counterpart of Xenopus/viper NT-4, which has many unusual features compared to the previously identified neurotrophins and is less conserved evolutionarily than the other neurotrophs.