Robin Browaeys

TL;DR: NicheNet is presented, a method that predicts ligand–target links between interacting cells by combining their expression data with prior knowledge on signaling and gene regulatory networks, and can infer active ligands and their gene regulatory effects on interacting cells.

TL;DR: It is shown that the Kupffer cell niche is composed of stellate cells, hepatocytes, and endothelial cells that together imprint the liver-specific macrophage identity.

TL;DR: In this paper , a hierarchical model of melanoma tumour growth was proposed, which mirrors the cellular and molecular logic underlying the cell-fate specification and differentiation of the embryonic neural crest, and suggests that the ability to support growth and metastasis are limited to distinct pools of cells.

TL;DR: In this article, a spatial proteogenomic atlas of the healthy human and murine liver combining single-cell CITE-seq, single-nuclei sequencing, spatial transcriptomics and spatial proteomics is presented.

TL;DR: This article showed that LTα1β2-expressing Rorgt+ ILC3s, together with B cells, control the splenic cDC niche size and the terminal differentiation of Sirpα+CD4+Esam+ cDC2s, independently of the microbiota and of bone marrow pre-cDC output.