Praveen K. Sappa

TL;DR: The transcriptomes of Bacillus subtilis exposed to a wide range of environmental and nutritional conditions that the organism might encounter in nature are reported, offering an initial understanding of why certain regulatory strategies may be favored during evolution of dynamic control systems.

TL;DR: An in-depth multi-omics analysis of the genome reduced strains revealed how the deletions affect the transcription regulatory network of the cell, translation resource allocation, and metabolism, and suggest the roads to further genome reduction to approach the final aim of a minimal cell in which all functions are understood.

TL;DR: A novel approach for the absolute quantification of proteins at a global scale has been developed and its applicability demonstrated using glucose starvation of the Gram-positive model bacterium Bacillus subtilis and the pathogen Staphylococcus aureus as proof-of-principle examples.

TL;DR: Surprisingly, the flux through central carbon and energy metabolism is very robust under all conditions studied, and increased production of several enzymes of central carbon metabolism compensates for their reduced activity in the presence of high salt.

TL;DR: The Kaplan–Meier survival analysis revealed a significant correlation of protein abundance of PRELP with postoperative survival of patients with PDAC, a potential new prognostic biomarker prolargin (PRELP).