F
François Lecointe
Researcher at Institut national de la recherche agronomique
Publications - 8
Citations - 1373
François Lecointe is an academic researcher from Institut national de la recherche agronomique. The author has contributed to research in topics: Bacillus subtilis & Biology. The author has an hindex of 5, co-authored 5 publications receiving 1221 citations. Previous affiliations of François Lecointe include Agro ParisTech.
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Journal ArticleDOI
Condition-Dependent Transcriptome Reveals High-Level Regulatory Architecture in Bacillus subtilis
Pierre Nicolas,Ulrike Mäder,Etienne Dervyn,Tatiana Rochat,Aurélie Leduc,Nathalie Pigeonneau,Elena Bidnenko,Elodie Marchadier,Mark Hoebeke,Stéphane Aymerich,Dörte Becher,Paola Bisicchia,Eric Botella,Olivier Delumeau,Geoff Doherty,Emma L. Denham,Mark J. Fogg,Vincent Fromion,Anne Goelzer,Annette Hansen,Elisabeth Härtig,Colin R. Harwood,Georg Homuth,Hanne Østergaard Jarmer,Matthieu Jules,Edda Klipp,Ludovic Le Chat,François Lecointe,Peter J. Lewis,Wolfram Liebermeister,Anika March,Ruben A. T. Mars,Priyanka Nannapaneni,David Noone,Susanne Pohl,Bernd Rinn,Frank Rügheimer,Praveen K. Sappa,Franck Samson,Marc Schaffer,Benno Schwikowski,Leif Steil,Jörg Stülke,Thomas Wiegert,Kevin M. Devine,Anthony J. Wilkinson,Jan Maarten van Dijl,Michael Hecker,Uwe Völker,Philippe Bessières,Philippe Noirot +50 more
TL;DR: The transcriptomes of Bacillus subtilis exposed to a wide range of environmental and nutritional conditions that the organism might encounter in nature are reported, offering an initial understanding of why certain regulatory strategies may be favored during evolution of dynamic control systems.
Journal ArticleDOI
Global Network Reorganization During Dynamic Adaptations of Bacillus subtilis Metabolism
Joerg Martin Buescher,Wolfram Liebermeister,Matthieu Jules,Markus Uhr,Jan Muntel,Eric Botella,Bernd Hessling,Roelco J. Kleijn,Ludovic Le Chat,François Lecointe,Ulrike Mäder,Pierre Nicolas,Sjouke Piersma,Frank Rügheimer,Dörte Becher,Philippe Bessières,Elena Bidnenko,Emma L. Denham,Etienne Dervyn,Kevin M. Devine,Geoff Doherty,Samuel Drulhe,Liza Felicori,Mark J. Fogg,Anne Goelzer,Annette Hansen,Colin R. Harwood,Michael Hecker,Sebastian Hubner,Claus Hultschig,Hanne Østergaard Jarmer,Edda Klipp,Aurélie Leduc,Peter J. Lewis,F. Molina,Philippe Noirot,Sabine Peres,Nathalie Pigeonneau,Susanne Pohl,Simon Rasmussen,Bernd Rinn,Marc Schaffer,Julian Schnidder,Benno Schwikowski,Jan Maarten van Dijl,Patrick Veiga,Sean Walsh,Anthony J. Wilkinson,Jörg Stelling,Stéphane Aymerich,Uwe Sauer +50 more
TL;DR: The responses of a bacterium to changing nutritional conditions are explored and an initial understanding of why certain regulatory strategies may be favored during evolution of dynamic control systems is offered.
Journal ArticleDOI
The C-terminal domain of the bacterial SSB protein acts as a DNA maintenance hub at active chromosome replication forks.
TL;DR: Findings show that the bacterial SSBCter acts as a DNA maintenance hub at active chromosomal forks that secures their propagation along the genome.
Journal ArticleDOI
Anticipating chromosomal replication fork arrest: SSB targets repair DNA helicases to active forks
François Lecointe,Céline Sérèna,Marion Velten,Audrey Costes,Stephen McGovern,Jean-Christophe Meile,Jean-Christophe Meile,Jeff Errington,Jeff Errington,S. Dusko Ehrlich,Philippe Noirot,Patrice Polard +11 more
TL;DR: It is reported that the single‐stranded DNA binding (SSB) protein is the key factor that links PriA to active chromosomal replication forks in vivo, providing a first line of rescue responses to accidental arrest.
Journal ArticleDOI
The dynamic protein partnership of RNA polymerase inBacillus subtilis.
Olivier Delumeau,Olivier Delumeau,François Lecointe,François Lecointe,Jan Muntel,Alain Guillot,Alain Guillot,Eric Guédon,Eric Guédon,Véronique Monnet,Véronique Monnet,Michael Hecker,Doerte Becher,Patrice Polard,Patrice Polard,Philippe Noirot,Philippe Noirot +16 more
TL;DR: The affinity‐purification of the Bacillus subtilis RNAP complexes from cells in different growth states and stress conditions, and the quantitative assessment by mass spectrometry of the dynamic changes in the composition of the RNAP complex are reported.