R
Ruben A. T. Mars
Researcher at Mayo Clinic
Publications - 25
Citations - 1823
Ruben A. T. Mars is an academic researcher from Mayo Clinic. The author has contributed to research in topics: Microbiome & Bacillus subtilis. The author has an hindex of 10, co-authored 22 publications receiving 1148 citations. Previous affiliations of Ruben A. T. Mars include University Medical Center Groningen & ETH Zurich.
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Journal ArticleDOI
Condition-Dependent Transcriptome Reveals High-Level Regulatory Architecture in Bacillus subtilis
Pierre Nicolas,Ulrike Mäder,Etienne Dervyn,Tatiana Rochat,Aurélie Leduc,Nathalie Pigeonneau,Elena Bidnenko,Elodie Marchadier,Mark Hoebeke,Stéphane Aymerich,Dörte Becher,Paola Bisicchia,Eric Botella,Olivier Delumeau,Geoff Doherty,Emma L. Denham,Mark J. Fogg,Vincent Fromion,Anne Goelzer,Annette Hansen,Elisabeth Härtig,Colin R. Harwood,Georg Homuth,Hanne Østergaard Jarmer,Matthieu Jules,Edda Klipp,Ludovic Le Chat,François Lecointe,Peter J. Lewis,Wolfram Liebermeister,Anika March,Ruben A. T. Mars,Priyanka Nannapaneni,David Noone,Susanne Pohl,Bernd Rinn,Frank Rügheimer,Praveen K. Sappa,Franck Samson,Marc Schaffer,Benno Schwikowski,Leif Steil,Jörg Stülke,Thomas Wiegert,Kevin M. Devine,Anthony J. Wilkinson,Jan Maarten van Dijl,Michael Hecker,Uwe Völker,Philippe Bessières,Philippe Noirot +50 more
TL;DR: The transcriptomes of Bacillus subtilis exposed to a wide range of environmental and nutritional conditions that the organism might encounter in nature are reported, offering an initial understanding of why certain regulatory strategies may be favored during evolution of dynamic control systems.
Journal ArticleDOI
Disentangling metabolic functions of bacteria in the honey bee gut.
Lucie Kešnerová,Ruben A. T. Mars,Kirsten M. Ellegaard,Michaël Troilo,Uwe Sauer,Philipp Engel +5 more
TL;DR: The honey bee gut microbiota utilizes a wide range of pollen-derived substrates, including flavonoids and outer pollen wall components, suggesting a key role for degradation of recalcitrant secondary plant metabolites and pollen digestion.
Journal ArticleDOI
Longitudinal Multi-omics Reveals Subset-Specific Mechanisms Underlying Irritable Bowel Syndrome.
Ruben A. T. Mars,Yi Yang,Tonya Ward,Mo Houtti,Sambhawa Priya,Heather Lekatz,Xiaojia Tang,Zhifu Sun,Krishna R. Kalari,Tal Korem,Tal Korem,Yogesh Bhattarai,Tenghao Zheng,Noam Bar,Gary Frost,Abigail J. Johnson,Will Van Treuren,Shuo Han,Tamas Ordog,Madhusudan Grover,Justin L. Sonnenburg,Mauro D'Amato,Michael Camilleri,Eran Elinav,Eran Segal,Ran Blekhman,Gianrico Farrugia,Jonathan R. Swann,Jonathan R. Swann,Dan Knights,Purna C. Kashyap +30 more
TL;DR: This study integrated longitudinal multi-omics data from the gut microbiome, metabolome, host epigenome, and transcriptome in the context of irritable bowel syndrome (IBS) host physiology to identify functional mechanisms that can serve as therapeutic targets in a comprehensive treatment strategy for chronic GI diseases.
Journal ArticleDOI
Metabolic cooperation and spatiotemporal niche partitioning in a kefir microbial community.
Sonja Blasche,Yongkyu Kim,Ruben A. T. Mars,Daniel Machado,Maria Maansson,Eleni Kafkia,Alessio Milanese,Georg Zeller,Bas Teusink,Jens Nielsen,Vladimir Benes,Rute Neves,Uwe Sauer,Kiran Raosaheb Patil +13 more
TL;DR: In this article, the authors show how kefir, a natural milk-fermenting community of prokaryotes (predominantly lactic and acetic acid bacteria) and yeasts (family Saccharomycetaceae), realizes stable coexistence through spatiotemporal orchestration of species and metabolite dynamics.
Posted ContentDOI
Disentangling metabolic functions of bacteria in the honey bee gut
Lucie Kešnerová,Ruben A. T. Mars,Kirsten M. Ellegaard,Michaël Troilo,Uwe Sauer,Philipp Engel +5 more
TL;DR: It is found that the gut microbiota digests recalcitrant substrates derived from the bees’ pollen-diet, and diverse metabolic functions of gut bacteria that are likely to contribute to bee health are revealed, and fundamental insights into how metabolic functions are partitioned within gut communities are provided.