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David Noone

Researcher at Trinity College, Dublin

Publications -  21
Citations -  5658

David Noone is an academic researcher from Trinity College, Dublin. The author has contributed to research in topics: Bacillus subtilis & Regulon. The author has an hindex of 17, co-authored 20 publications receiving 5386 citations.

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The complete genome sequence of the Gram-positive bacterium Bacillus subtilis

F. Kunst, +154 more
- 20 Nov 1997 - 
TL;DR: Bacillus subtilis is the best-characterized member of the Gram-positive bacteria, indicating that bacteriophage infection has played an important evolutionary role in horizontal gene transfer, in particular in the propagation of bacterial pathogenesis.
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Condition-Dependent Transcriptome Reveals High-Level Regulatory Architecture in Bacillus subtilis

TL;DR: The transcriptomes of Bacillus subtilis exposed to a wide range of environmental and nutritional conditions that the organism might encounter in nature are reported, offering an initial understanding of why certain regulatory strategies may be favored during evolution of dynamic control systems.
Journal ArticleDOI

The essential YycFG two‐component system controls cell wall metabolism in Bacillus subtilis

TL;DR: It is shown that a yvcE lytE double mutant strain is not viable and that cells lacking LytE and depleted for YvcE exhibit defects in lateral cell wall synthesis and cell elongation.
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Genes controlled by the essential YycG/YycF two-component system of Bacillus subtilis revealed through a novel hybrid regulator approach.

TL;DR: Using a combined hybrid regulator/transcriptome approach involving the inducible expression of a PhoP′‐′YycF chimerical protein in B. subtilis, it is shown that expression of yocH, which encodes a potential autolysin, is specifically activated by YyCF.
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A novel class of heat and secretion stress-responsive genes is controlled by the autoregulated CssRS two-component system of Bacillus subtilis.

TL;DR: This study shows that CssRS-regulated genes represent a novel class of heat-inducible genes, which is referred to as class V and currently includes two genes: htrA and htrB, which are responsive to heat and secretion stress.