R
Raquel Planas
Researcher at University of Zurich
Publications - 34
Citations - 1613
Raquel Planas is an academic researcher from University of Zurich. The author has contributed to research in topics: Immune system & Antigen. The author has an hindex of 23, co-authored 33 publications receiving 1357 citations. Previous affiliations of Raquel Planas include Autonomous University of Barcelona & University of Hamburg.
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Journal ArticleDOI
Memory B Cells Activate Brain-Homing, Autoreactive CD4+ T Cells in Multiple Sclerosis.
Ivan Jelcic,Faiez Al Nimer,Faiez Al Nimer,Jian Wang,Verena Lentsch,Raquel Planas,Ilijas Jelcic,Aleksandar Madjovski,Sabrina Ruhrmann,Wolfgang Faigle,Katrin Frauenknecht,Clemencia Pinilla,Radleigh G. Santos,Christian Hammer,Christian Hammer,Yanneth Ortiz,Lennart Opitz,Hans Grönlund,Gerhard Rogler,Onur Boyman,Richard Reynolds,Andreas Lutterotti,Mohsen Khademi,Tomas Olsson,Frederik Piehl,Mireia Sospedra,Roland Martin +26 more
TL;DR: It is demonstrated that self-reactivity, defined as “autoproliferation” of peripheral Th1 cells, is elevated in patients carrying the HLA-DR15 haplotype, and RASGRP2 is identified as target autoantigen that is expressed in the brain and B cells.
Journal ArticleDOI
Peripheral and Islet Interleukin-17 Pathway Activation Characterizes Human Autoimmune Diabetes and Promotes Cytokine-Mediated β-Cell Death
Sefina Arif,Fabrice Moore,Katherine Marks,Thomas Bouckenooghe,Colin M. Dayan,Raquel Planas,Marta Vives-Pi,Jake Powrie,Timothy Tree,Piero Marchetti,Guo Cai Huang,Esteban Nicolas Gurzov,Ricardo Pujol-Borrell,Decio L. Eizirik,Mark Peakman +14 more
TL;DR: It is shown that IL-17 mediates significant and reproducible enhancement of IL-1β/interferon (IFN)-γ–induced and tumor necrosis factor (TNF)-α/IFN-γ-induced apoptosis in human islets, rat β-cells, and INS-1E cells, in association with significant upregulation of β-cell IL17RA expression via activation of the transcription factors STAT1 and nuclear factor (NF)-κB.
Journal ArticleDOI
Natalizumab treatment perturbs memory- and marginal zone-like B-cell homing in secondary lymphoid organs in multiple sclerosis.
Raquel Planas,Ilijas Jelcic,Sven Schippling,Sven Schippling,Roland Martin,Roland Martin,Mireia Sospedra,Mireia Sospedra +7 more
TL;DR: The ability of natalizumab to influence B‐cell migration and homeostasis through the splenic MZ, where JCV has been detected, adds to the list of nalozumab effects and may contribute to PML development by disseminating JCV.
Journal ArticleDOI
Gene expression profiles for the human pancreas and purified islets in Type 1 diabetes: new findings at clinical onset and in long-standing diabetes
Raquel Planas,Jorge Carrillo,Alex Sánchez,Alex Sánchez,M. C. Ruiz de Villa,F Nuñez,Joan Verdaguer,Roger F.L. James,Ricardo Pujol-Borrell,Marta Vives-Pi +9 more
TL;DR: In this paper, the authors reported whole genome transcript analysis validated by quantitative reverse transcription-polymerase chain reaction (qRT-PCR) and correlated with immunohistological observations for four Type 1 diabetes patients and for purified islets from two of them.
Journal ArticleDOI
GDP-l-fucose synthase is a CD4+ T cell–specific autoantigen in DRB3*02:02 patients with multiple sclerosis
Raquel Planas,Radleigh G. Santos,Paula Tomas-Ojer,Carolina Cruciani,Andreas Lutterotti,Wolfgang Faigle,Nicole Schaeren-Wiemers,Carmen Espejo,Herena Eixarch,Clemencia Pinilla,Roland Martin,Mireia Sospedra +11 more
TL;DR: GDP-l-fucose synthase is an autoantigen recognized by cerebrospinal fluid–infiltrating CD4+ T cells from HLA-DRB3*–positive patients with multiple sclerosis, and the possible role of this antigen as an inducer or driver of pathogenic autoimmune responses in multiple sclerosis is suggested.