R
Rasha Msallam
Researcher at Agency for Science, Technology and Research
Publications - 11
Citations - 919
Rasha Msallam is an academic researcher from Agency for Science, Technology and Research. The author has contributed to research in topics: Tumor necrosis factor alpha & Immune system. The author has an hindex of 9, co-authored 11 publications receiving 581 citations. Previous affiliations of Rasha Msallam include Singapore Immunology Network & Paris Descartes University.
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Journal ArticleDOI
Hemogenic Endothelial Fate Mapping Reveals Dual Developmental Origin of Mast Cells.
Rebecca Gentek,Clément Ghigo,Guillaume Hoeffel,Guillaume Hoeffel,Maxime Jacques Bulle,Rasha Msallam,Gregory Gautier,Pierre Launay,Jinmiao Chen,Florent Ginhoux,Marc Bajénoff +10 more
TL;DR: It is concluded that within myeloid lineages, dual hematopoietic origin is shared between macrophages and MCs, which means mast cells are yolk sac derived in the embryo but replaced by definitive hematoiesis in the adult.
Journal ArticleDOI
Microglial Function Is Distinct in Different Anatomical Locations during Retinal Homeostasis and Degeneration
Emily G. O’Koren,Chen Yu,Mikael Klingeborn,Alicia Y. W. Wong,Cameron L. Prigge,Rose Mathew,Joan Kalnitsky,Rasha Msallam,Aymeric Silvin,Jeremy N. Kay,Catherine Bowes Rickman,Vadim Y. Arshavsky,Florent Ginhoux,Miriam Merad,Daniel R. Saban +14 more
TL;DR: It is shown that adult retinal microglia shared a common developmental lineage and were long‐lived but resided in two distinct niches, and that microglial function varies by retinal niche, thereby shedding light on the significance of microglian heterogeneity.
Journal ArticleDOI
Human fetal dendritic cells promote prenatal T-cell immune suppression through arginase-2
Naomi McGovern,Amanda Shin,Amanda Shin,Gillian Low,Donovan Low,Kaibo Duan,Leong Jing Yao,Rasha Msallam,Ivy Low,Nurhidaya Binte Shadan,Hermi Sumatoh,Erin Soon,Josephine Lum,Esther Wing Hei Mok,Sandra Hubert,Peter See,Edwin Huang Kunxiang,Yie Hou Lee,Yie Hou Lee,Baptiste Janela,Mahesh Choolani,Citra Nurfarah Zaini Mattar,Yiping Fan,Yiping Fan,Tony Kiat Hon Lim,Dedrick Kok Hong Chan,Ker-Kan Tan,Ker-Kan Tan,John Kit Chung Tam,Christopher Schuster,Adelheid Elbe-Bürger,Xiao-Nong Wang,Venetia Bigley,Matthew Collin,Muzlifah Haniffa,Andreas Schlitzer,Andreas Schlitzer,Andreas Schlitzer,Michael Poidinger,Salvatore Albani,Anis Larbi,Evan W. Newell,Jerry Kok Yen Chan,Florent Ginhoux +43 more
TL;DR: The results reveal a previously unappreciated role of dendritic cells within the developing fetus and indicate that they mediate homeostatic immune-suppressive responses during gestation.
Journal ArticleDOI
Mast cells aggravate sepsis by inhibiting peritoneal macrophage phagocytosis
Albert Dahdah,Gregory Gautier,Tarik Attout,Frédéric Di Fiore,Emeline Lebourdais,Rasha Msallam,Marc Daëron,Renato C. Monteiro,Marc Benhamou,Nicolas Charles,Jean Davoust,Ulrich Blank,Bernard Malissen,Pierre Launay +13 more
TL;DR: A local crosstalk between mast cells and macrophages during the early phase of sepsis development that aggravates the outcome of severe bacterial infection is uncovered.
Journal ArticleDOI
Epidermal γδ T cells originate from yolk sac hematopoiesis and clonally self-renew in the adult.
Rebecca Gentek,Clément Ghigo,Guillaume Hoeffel,Guillaume Hoeffel,Audrey Jorquera,Rasha Msallam,Stephan Wienert,Frederick Klauschen,Florent Ginhoux,Florent Ginhoux,Marc Bajénoff +10 more
TL;DR: DETCs resemble LCs concerning their maintenance, replenishment mechanisms, and hematopoietic development, suggesting that the epidermal microenvironment exerts a lineage-independent influence on the initial seeding and homeostatic maintenance of its resident immune cells.