R
Raymond Wu
Researcher at University of Southern California
Publications - 43
Citations - 1532
Raymond Wu is an academic researcher from University of Southern California. The author has contributed to research in topics: Enterprise integration & Internet security. The author has an hindex of 12, co-authored 42 publications receiving 1150 citations. Previous affiliations of Raymond Wu include University of California, San Diego & IBM.
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Journal ArticleDOI
Target identification using drug affinity responsive target stability (DARTS)
Brett Lomenick,Rui Hao,Nao Jonai,Randall Chin,Mariam Aghajan,Sarah Warburton,Jianing Wang,Raymond Wu,Fernando Gomez,Joseph A. Loo,James A. Wohlschlegel,Thomas M. Vondriska,Jerry Pelletier,Harvey R. Herschman,Jon Clardy,Catherine F. Clarke,Jing Huang +16 more
TL;DR: In this paper, drug affinity responsive target stability (DARTS) is proposed to identify known small-molecule-protein interactions and reveal the eukaryotic translation initiation machinery as a molecular target for the longevity enhancing plant natural product resveratrol.
Journal ArticleDOI
Pyroptosis by caspase11/4-gasdermin-D pathway in alcoholic hepatitis in mice and patients.
Elena Khanova,Raymond Wu,Wen Wang,Rui Yan,Yibu Chen,Samuel W. French,Cristina Llorente,Stephanie Q. Pan,Qihong Yang,Yuchang Li,Raul Lazaro,Charles Ansong,Richard D. Smith,Ramon Bataller,Timothy R. Morgan,Bernd Schnabl,Hidekazu Tsukamoto,Hidekazu Tsukamoto +17 more
TL;DR: These results implicate pyroptosis induced by the CASP11/4‐GSDMD pathway in the pathogenesis of AH.
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Stearoyl-CoA Desaturase Promotes Liver Fibrosis and Tumor Development in Mice via a Wnt Positive-Signaling Loop by Stabilization of Low-Density Lipoprotein-Receptor-Related Proteins 5 and 6
Keane K. Y. Lai,Soo-Mi Kweon,Feng Chi,Edward Hwang,Yasuaki Kabe,Reiichi Higashiyama,Lan Qin,Rui Yan,Raymond Wu,Keith Lai,Naoaki Fujii,Samuel W. French,Samuel W. French,Jun Xu,Jian Ying Wang,Ramachandran Murali,Ramachandran Murali,Lopa Mishra,Ju Seog Lee,James M. Ntambi,Hidekazu Tsukamoto,Hidekazu Tsukamoto +21 more
TL;DR: In rodent HSCs and TICs, SCD expression was found to be regulated by Wnt-β-catenin signaling, and MUFAs produced by SCD provided a forward loop to amplify Wnt signaling via stabilization of Lrp5 and LRp6 mRNAs, contributing to liver fibrosis and tumor growth.
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Nrf2 responses and the therapeutic selectivity of electrophilic compounds in chronic lymphocytic leukemia
Raymond Wu,Tomoko Hayashi,Howard B. Cottam,Guangyi Jin,Shiyin Yao,Christina C.N. Wu,Michael Rosenbach,Maripat Corr,Richard Schwab,Dennis A. Carson +9 more
TL;DR: The presence of Nrf2 signaling in human CLL is documented and altered NRF2 responses may contribute to the observed selective cytotoxicity of electrophilic compounds in this disease.
Journal ArticleDOI
Osteopontin deficiency does not prevent but promotes alcoholic neutrophilic hepatitis in mice
Raul Lazaro,Raymond Wu,Sunyoung Lee,Nian-Ling Zhu,Chia-Lin Chen,Samuel W. French,Jun Xu,Keigo Machida,Hidekazu Tsukamoto +8 more
TL;DR: SPP1 deficiency does not reduce AH incidence and inductions of progenitor and fibrogenic genes, but rather enhances the Il‐17a induction and PMN infiltration in some mice, suggesting that SPP1 has a protective, rather than causal, role for experimental AH reproduced in this model.