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Rebecca A. Garlena
Researcher at University of Pittsburgh
Publications - 62
Citations - 1643
Rebecca A. Garlena is an academic researcher from University of Pittsburgh. The author has contributed to research in topics: Genome & Bacteriophage. The author has an hindex of 12, co-authored 56 publications receiving 924 citations. Previous affiliations of Rebecca A. Garlena include Gonzaga University.
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Journal ArticleDOI
Engineered bacteriophages for treatment of a patient with a disseminated drug-resistant Mycobacterium abscessus
Rebekah M. Dedrick,Carlos A Guerrero-Bustamante,Rebecca A. Garlena,Daniel A. Russell,Katrina Ford,Kathryn A. Harris,Kimberly Gilmour,James Soothill,Deborah Jacobs-Sera,Robert T. Schooley,Graham F. Hatfull,Helen Spencer +11 more
TL;DR: Intravenous phage treatment was well tolerated and associated with objective clinical improvement, including sternal wound closure, improved liver function, and substantial resolution of infected skin nodules.
Journal ArticleDOI
Prophage-mediated defence against viral attack and viral counter-defence.
Rebekah M. Dedrick,Deborah Jacobs-Sera,Carlos A. Guerrero Bustamante,Rebecca A. Garlena,Travis N. Mavrich,Welkin H. Pope,Juan C. Cervantes Reyes,Daniel A. Russell,Tamarah L. Adair,Richard M Alvey,J. Alfred Bonilla,Jerald S. Bricker,Bryony R. Brown,Deanna Byrnes,Steven G. Cresawn,William B. Davis,Leon A. Dickson,Nicholas P. Edgington,Ann M. Findley,Urszula Golebiewska,Julianne H. Grose,Cory F. Hayes,Lee E. Hughes,Keith W. Hutchison,Sharon Isern,Allison Johnson,Margaret A. Kenna,Karen K. Klyczek,Catherine M. Mageeney,Scott F. Michael,Sally D. Molloy,Matthew T. Montgomery,James Neitzel,Shallee T. Page,Marie C. Pizzorno,Marianne K. Poxleitner,Claire A. Rinehart,Courtney J. Robinson,Michael R. Rubin,Joseph N. Teyim,Edwin Vazquez,Vassie C. Ware,Jacqueline Washington,Graham F. Hatfull +43 more
TL;DR: Characterization of ten Cluster N temperate mycobacteriophages revealed at least five distinct prophage-expressed viral defence systems that interfere with the infection of lytic and temperate phages that are either closely related (homotypic defence) or unrelated (heterotypic Defence) to the prophages.
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An inclusive Research Education Community (iREC): Impact of the SEA-PHAGES program on research outcomes and student learning.
David I. Hanauer,Mark J. Graham,Sea-Phages,Laura Betancur,Aiyana Bobrownicki,Steven G. Cresawn,Rebecca A. Garlena,Deborah Jacobs-Sera,Nancy Kaufmann,Welkin H. Pope,Daniel A. Russell,William R. Jacobs,Viknesh Sivanathan,David J. Asai,Graham F. Hatfull +14 more
TL;DR: The SEA-PHAGES students show strong gains correlated with persistence relative to those in traditional laboratory courses regardless of academic, ethnic, gender, and socioeconomic profiles.
Journal ArticleDOI
Bacteriophages of Gordonia spp. Display a Spectrum of Diversity and Genetic Relationships.
Welkin H. Pope,Travis N. Mavrich,Rebecca A. Garlena,Carlos A Guerrero-Bustamante,Deborah Jacobs-Sera,Matthew T. Montgomery,Daniel A. Russell,Marcie H. Warner,Graham F. Hatfull +8 more
TL;DR: It is suggested that any barriers to genetic exchange are soft and readily violable, and further isolation and genomic comparison of phages targeted at related groups of hosts promise to reveal pathways of bacteriophage evolution.
Journal ArticleDOI
More Evidence of Collusion: a New Prophage-Mediated Viral Defense System Encoded by Mycobacteriophage Sbash.
Gabrielle M. Gentile,Katherine S. Wetzel,Rebekah M. Dedrick,Matthew T. Montgomery,Rebecca A. Garlena,Deborah Jacobs-Sera,Graham F. Hatfull +6 more
TL;DR: A new viral defense system is described in which the mycobacteriophage Sbash prophage colludes with its MyCobacterium smegmatis host to confer highly specific defense against infection by the unrelated myc Cobacteriophile Crossroads.