L
Lee E. Hughes
Researcher at University of North Texas
Publications - 24
Citations - 890
Lee E. Hughes is an academic researcher from University of North Texas. The author has contributed to research in topics: Genome & Lysogenic cycle. The author has an hindex of 10, co-authored 24 publications receiving 675 citations.
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Journal ArticleDOI
A Broadly Implementable Research Course in Phage Discovery and Genomics for First-Year Undergraduate Students
Tuajuanda C. Jordan,Sandra H. Burnett,Susan Carson,Steven M. Caruso,Kari Clase,Randall J. DeJong,John J. Dennehy,Dee R. Denver,David Dunbar,Sarah C. R. Elgin,Ann M. Findley,Chris R. Gissendanner,Urszula Golebiewska,Nancy Guild,Grant A. Hartzog,Wendy H. Grillo,Gail P. Hollowell,Lee E. Hughes,Allison Johnson,Rodney A. King,Lynn O. Lewis,Wei Li,Frank Rosenzweig,Michael R. Rubin,Margaret S. Saha,James Sandoz,Christopher D. Shaffer,Barbara J. Taylor,Larissa K. Temple,Edwin Vazquez,Vassie C. Ware,Lucia P. Barker,Kevin W. Bradley,Deborah Jacobs-Sera,Welkin H. Pope,Daniel A. Russell,Steven G. Cresawn,David Lopatto,Cheryl Bailey,Graham F. Hatfull +39 more
TL;DR: A general model in which faculty and teaching assistants from diverse academic institutions are trained to teach a research course for first-year undergraduate students focused on bacteriophage discovery and genomics is developed, showing that this alliance-sourced model not only substantially advances the field of phage genomics but also stimulates students’ interest in science, positively influences academic achievement, and enhances persistence inScience, technology, engineering, and mathematics (STEM) disciplines.
Journal ArticleDOI
Prophage-mediated defence against viral attack and viral counter-defence.
Rebekah M. Dedrick,Deborah Jacobs-Sera,Carlos A. Guerrero Bustamante,Rebecca A. Garlena,Travis N. Mavrich,Welkin H. Pope,Juan C. Cervantes Reyes,Daniel A. Russell,Tamarah L. Adair,Richard M Alvey,J. Alfred Bonilla,Jerald S. Bricker,Bryony R. Brown,Deanna Byrnes,Steven G. Cresawn,William B. Davis,Leon A. Dickson,Nicholas P. Edgington,Ann M. Findley,Urszula Golebiewska,Julianne H. Grose,Cory F. Hayes,Lee E. Hughes,Keith W. Hutchison,Sharon Isern,Allison Johnson,Margaret A. Kenna,Karen K. Klyczek,Catherine M. Mageeney,Scott F. Michael,Sally D. Molloy,Matthew T. Montgomery,James Neitzel,Shallee T. Page,Marie C. Pizzorno,Marianne K. Poxleitner,Claire A. Rinehart,Courtney J. Robinson,Michael R. Rubin,Joseph N. Teyim,Edwin Vazquez,Vassie C. Ware,Jacqueline Washington,Graham F. Hatfull +43 more
TL;DR: Characterization of ten Cluster N temperate mycobacteriophages revealed at least five distinct prophage-expressed viral defence systems that interfere with the infection of lytic and temperate phages that are either closely related (homotypic defence) or unrelated (heterotypic Defence) to the prophages.
Journal ArticleDOI
Cluster K Mycobacteriophages: Insights into the Evolutionary Origins of Mycobacteriophage TM4
Welkin H. Pope,Christina M. Ferreira,Deborah Jacobs-Sera,Robert C. Benjamin,Ariangela J. Davis,Randall J. DeJong,Sarah C. R. Elgin,Forrest R. Guilfoile,Mark H. Forsyth,Alexander D. Harris,Samuel E. Harvey,Lee E. Hughes,Peter M. Hynes,Arrykka S. Jackson,Marilyn D. Jalal,Elizabeth A. MacMurray,Coreen M. Manley,Molly J. McDonough,Jordan L. Mosier,Larissa J. Osterbann,H. S. Rabinowitz,Corwin N. Rhyan,Daniel A. Russell,Margaret S. Saha,Christopher D. Shaffer,Stephanie E. Simon,Erika Fieldman Sims,Isabel G. Tovar,Emilie G. Weisser,John T. Wertz,Kathleen Weston-Hafer,Kurt E. Williamson,Bo Zhang,Steven G. Cresawn,Paras Jain,Mariana Piuri,William R. Jacobs,Roger W. Hendrix,Graham F. Hatfull +38 more
TL;DR: It is suggested that TM4 is a recent derivative of a temperate parent, resolving a long-standing conundrum about its biology, in that it was reportedly recovered from a lysogenic strain of Mycobacterium avium, but it is not capable of forming lysogens in any mycobacterial host.
Journal ArticleDOI
Cluster M mycobacteriophages Bongo, PegLeg, and Rey with unusually large repertoires of tRNA isotypes
Welkin H. Pope,Kirk R. Anders,Madison A. Baird,Charles A. Bowman,Michelle M. Boyle,Gregory W. Broussard,Tiffany W. Chow,Kari Clase,Shannon D. Cooper,Kathleen Cornely,Randall J. DeJong,Véronique A. Delesalle,Lisa Deng,David Dunbar,Nicholas P. Edgington,Christina M. Ferreira,Kathleen Weston Hafer,Grant A. Hartzog,J. Robert Hatherill,Lee E. Hughes,Khristina Ipapo,Gregory P. Krukonis,Christopher G Meier,Denise L Monti,Matthew R. Olm,Shallee T. Page,Craig L. Peebles,Claire A. Rinehart,Michael R. Rubin,Daniel A. Russell,Erin R. Sanders,Morgan Schoer,Christopher D. Shaffer,James Wherley,Edwin Vazquez,Han Yuan,Daiyuan Zhang,Steven G. Cresawn,Deborah Jacobs-Sera,Roger W. Hendrix,Graham F. Hatfull +40 more
TL;DR: Three new phages constituting a new cluster M further expand the diversity of the mycobacteriophages and introduce novel features, providing insights into phage genome architecture, virion structure, and gene regulation at the transcriptional and translational levels.
Journal ArticleDOI
Genomic Diversity of Bacteriophages Infecting Microbacterium SPP
Deborah Jacobs-Sera,Lawrence Abad,Richard M Alvey,Kirk R. Anders,Haley G. Aull,Suparna S. Bhalla,Lawrence S. Blumer,David Bollivar,J. Alfred Bonilla,Kristen Butela,Roy J. Coomans,Steven G. Cresawn,Tom D’Elia,Arturo Diaz,Ashley M. Divens,Nicholas P. Edgington,Gregory D. Frederick,Maria D. Gainey,Rebecca A. Garlena,Kenneth W. Grant,Susan M. R. Gurney,Heather Hendrickson,Lee E. Hughes,Margaret A. Kenna,Karen K. Klyczek,Hari Kotturi,Travis N. Mavrich,Angela L. McKinney,Evan C. Merkhofer,Jordan Moberg Parker,Sally D. Molloy,Denise L Monti,Dana A. Pape-Zambito,Richard S. Pollenz,Welkin H. Pope,Nathan S. Reyna,Claire A. Rinehart,Daniel A. Russell,Christopher D. Shaffer,Viknesh Sivanathan,Ty H. Stoner,Joseph Stukey,C. Nicole Sunnen,Sara S. Tolsma,Philippos K. Tsourkas,Jamie R. Wallen,Vassie C. Ware,Marcie H. Warner,Jacqueline Washington,Kristi M. Westover,JoAnn L. Whitefleet-Smith,Helen Wiersma-Koch,Daniel C Williams,Kira M. Zack,Graham F. Hatfull +54 more
TL;DR: The isolation and genomic characterization of 116 phages that infect Microbacterium spp.