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Rebecca L. Podyminogin
Researcher at Seattle Biomed
Publications - 7
Citations - 534
Rebecca L. Podyminogin is an academic researcher from Seattle Biomed. The author has contributed to research in topics: Viral replication & Virus. The author has an hindex of 6, co-authored 7 publications receiving 422 citations. Previous affiliations of Rebecca L. Podyminogin include Center for Infectious Disease Research and Policy.
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Journal ArticleDOI
25-Hydroxycholesterol acts as an amplifier of inflammatory signaling
Elizabeth S. Gold,Alan H. Diercks,Irina Podolsky,Rebecca L. Podyminogin,Peter S. Askovich,Piper M. Treuting,Alan Aderem +6 more
TL;DR: This study demonstrates, for the first time, that in addition to its direct antiviral role, 25HC also regulates transcriptional responses and acts as an amplifier of inflammation via AP-1 and that the resulting alteration in inflammatory response leads to increased tissue damage in mice following infection with influenza.
Journal ArticleDOI
miR-451 Regulates Dendritic Cell Cytokine Responses to Influenza Infection
Carrie M. Rosenberger,Rebecca L. Podyminogin,Garnet Navarro,Guowei Zhao,Peter S. Askovich,Mitchell J. Weiss,Alan Aderem +6 more
TL;DR: The data suggest that viral infection specifically induces a miRNA that directs a negative regulatory cascade to tune DC cytokine production, and this work determined that miR-451 regulates a subset of proinflammatory cytokine responses.
Journal ArticleDOI
miR-144 attenuates the host response to influenza virus by targeting the TRAF6-IRF7 signaling axis
Carrie M. Rosenberger,Rebecca L. Podyminogin,Alan H. Diercks,Piper M. Treuting,Jacques J. Peschon,David Rodriguez,Madhumati Gundapuneni,Mitchell J. Weiss,Alan Aderem +8 more
TL;DR: It is suggested that miR-144 reduces the antiviral response by attenuating the TRAF6-IRF7 pathway to alter the cellular antiviral transcriptional landscape.
Journal ArticleDOI
Safety and Immunogenicity of the Recombinant BCG Vaccine AERAS-422 in Healthy BCG-naïve Adults: A Randomized, Active-controlled, First-in-human Phase 1 Trial.
Daniel F. Hoft,Azra Blazevic,Asmir Selimovic,Aldin Turan,Jan Tennant,Getahun Abate,John Fulkerson,Daniel E. Zak,Robert Walker,Bruce McClain,J. Sadoff,Judy Scott,Barbara Shepherd,Jasur Ishmukhamedov,David A. Hokey,Veerabadran Dheenadhayalan,Smitha Shankar,Lynn M. Amon,Garnet Navarro,Rebecca L. Podyminogin,Alan Aderem,Lew Barker,Michael J. Brennan,Robert S. Wallis,Anne A. Gershon,Michael D. Gershon,Sharon Steinberg +26 more
TL;DR: High dose AERAS-422 vaccination induced Ag85A- and Ag85B-specific lymphoproliferative responses and marked anti-mycobacterial activity in a whole blood bactericidal activity culture assay (WBA), but was associated with varicella zoster virus (VZV) reactivation in two vaccinees.
Journal ArticleDOI
A comprehensive collection of systems biology data characterizing the host response to viral infection
Brian D. Aevermann,Brett E. Pickett,Sanjeev Kumar,Edward B. Klem,Sudhakar Agnihothram,Peter S. Askovich,Armand Bankhead,Armand Bankhead,Meagen Bolles,Victoria S. Carter,Jean Chang,Therese R. W. Clauss,Pradyot Dash,Alan H. Diercks,Amie J. Eisfeld,Amy B. Ellis,Shufang Fan,Martin T. Ferris,Lisa E. Gralinski,Richard Green,Marina A. Gritsenko,Masato Hatta,Robert A. Heegel,Jon M. Jacobs,Sophia Jeng,Laurence Josset,Shari M. Kaiser,Sara M. Kelly,G. Lynn Law,Chengjun Li,Jiangning Li,Casey Long,Maria L. Luna,Melissa M. Matzke,Jason E. McDermott,Vineet D. Menachery,Thomas O. Metz,Hugh D. Mitchell,Matthew E. Monroe,Garnet Navarro,Gabriele Neumann,Rebecca L. Podyminogin,Samuel O. Purvine,Carrie M. Rosenberger,Carrie M. Rosenberger,Catherine J. Sanders,Athena A. Schepmoes,Anil K. Shukla,Amy C. Sims,Pavel Sova,Vincent C. Tam,Nicolas Tchitchek,Paul G. Thomas,Susan C. Tilton,Allison L. Totura,Jing Wang,Bobbie-Jo M. Webb-Robertson,Ji Wen,Jeffrey M. Weiss,Feng Yang,Boyd Yount,Qibin Zhang,Shannon K. McWeeney,Shannon K. McWeeney,Richard D. Smith,Katrina M. Waters,Yoshihiro Kawaoka,Ralph S. Baric,Alan Aderem,Michael G. Katze,Richard H. Scheuermann,Richard H. Scheuermann +71 more
TL;DR: By comparing data from mutant versus wild-type virus and host strains, RNA versus protein differential expression, and infection with genetically similar strains, these data can be used to further investigate genetic and physiological determinants of host responses to viral infection.