R
Roberto R. Moraes Barros
Researcher at National Institutes of Health
Publications - 20
Citations - 507
Roberto R. Moraes Barros is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Plasmodium vivax & Plasmodium falciparum. The author has an hindex of 11, co-authored 17 publications receiving 399 citations. Previous affiliations of Roberto R. Moraes Barros include Federal University of São Paulo.
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Journal ArticleDOI
Bone Marrow Is a Major Parasite Reservoir in Plasmodium vivax Infection.
Nicanor Obaldia,Nicanor Obaldia,Elamaran Meibalan,Elamaran Meibalan,Juliana M. Sá,Siyuan Ma,Martha A. Clark,Pedro Mejia,Roberto R. Moraes Barros,William Otero,Marcelo U. Ferreira,James R. Mitchell,Danny A. Milner,Curtis Huttenhower,Dyann F. Wirth,Manoj T. Duraisingh,Thomas E. Wellems,Matthias Marti,Matthias Marti +18 more
TL;DR: It is suggested that the bone marrow is an important reservoir for gametocyte development and proliferation of malaria parasites, and a systematic examination of tissue sequestration during P. vivax infection has important implications for parasite diagnosis and treatment.
Journal ArticleDOI
Genome Size, Karyotype Polymorphism and Chromosomal Evolution in Trypanosoma cruzi
Renata T. Souza,Fabio Mitsuo Lima,Roberto R. Moraes Barros,Danielle Rodrigues Cortez,Michele Fernandes Santos,Esteban Mauricio Cordero,Jeronimo C. Ruiz,Samuel Goldenberg,Marta Maria Geraldes Teixeira,José Franco da Silveira +9 more
TL;DR: Despite genome size variation and karyotype polymorphism, T. cruzi lineages exhibit conservation of chromosome structure, and several syntenic groups are conserved among all isolates analyzed in this study.
Journal ArticleDOI
Artemisinin resistance phenotypes and K13 inheritance in a Plasmodium falciparum cross and Aotus model.
Juliana M. Sá,Sarah R. Kaslow,Michael Krause,Viviana A. Melendez-Muniz,Rebecca E. Salzman,Whitney A. Kite,Min Zhang,Roberto R. Moraes Barros,Jianbing Mu,Paul K. J. Han,J. Patrick Mershon,Christine E. Figan,Ramoncito L. Caleon,Rifat S. Rahman,Tyler J. Gibson,Chanaki Amaratunga,Erika P. Nishiguchi,Kimberly F Breglio,Theresa Engels,Soundarapandian Velmurugan,Stacy M. Ricklefs,Judith Straimer,Nina F. Gnädig,Bingbing Deng,Anna Liu,Ababacar Diouf,Kazutoyo Miura,Gregory Tullo,Richard T. Eastman,Sumana Chakravarty,Eric R. James,Kenneth O. Udenze,Suzanne Li,Daniel E. Sturdevant,Robert W. Gwadz,Stephen F. Porcella,Carole A. Long,David A. Fidock,Marvin L. Thomas,Michael P. Fay,B. Kim Lee Sim,Stephen L. Hoffman,John H. Adams,Rick M. Fairhurst,Xin-zhuan Su,Thomas E. Wellems +45 more
TL;DR: A P. falciparum laboratory cross of K13 C580Y mutant with C580 wild-type parasites is described to investigate ART response phenotypes in vitro and in vivo and emphasize the need for improved partner drugs to effectively eliminate the parasites that persist through the ART component of combination therapy.
Journal ArticleDOI
Anatomy and evolution of telomeric and subtelomeric regions in the human protozoan parasite Trypanosoma cruzi.
Roberto R. Moraes Barros,Marjorie Mendes Marini,Cristiane Regina Antonio,Danielle Rodrigues Cortez,Andrea Midory Miyake,Fabio Mitsuo Lima,Jeronimo C. Ruiz,Daniella Castanheira Bartholomeu,Miguel Angel Chiurillo,José Luis Ramírez,José Franco da Silveira +10 more
TL;DR: The lack of synteny in the subtelomeric regions of T. cruzi suggests that genes located in these regions are subject to recombination, which increases their variability, even among homologous chromosomes.
Journal ArticleDOI
Plasmodium vivax chloroquine resistance links to pvcrt transcription in a genetic cross.
Juliana M. Sá,Sarah R. Kaslow,Roberto R. Moraes Barros,Nicholas F Brazeau,Christian M. Parobek,Dingyin Tao,Rebecca E. Salzman,Tyler J. Gibson,Soundarapandian Velmurugan,Michael Krause,Viviana A. Melendez-Muniz,Whitney A. Kite,Paul K. J. Han,Richard T. Eastman,Adam Kim,Evan G. Kessler,Yonas Abebe,Eric R. James,Sumana Chakravarty,Sachy Orr-Gonzalez,Lynn Lambert,Theresa Engels,Marvin L. Thomas,Pius S. Fasinu,David Serre,Robert W. Gwadz,Larry A. Walker,Derrick K. DeConti,Jianbing Mu,Jeffrey A. Bailey,Jeffrey A. Bailey,B. Kim Lee Sim,Stephen L. Hoffman,Michael P. Fay,Rhoel R. Dinglasan,Rhoel R. Dinglasan,Jonathan J. Juliano,Thomas E. Wellems +37 more
TL;DR: A cross of Plasmodium vivax malaria parasites links a chloroquine resistance (CQR) phenotype to a 76 kb region of chromosome 1 and greater expression of pvcrt, an ortholog of the Plas modium falciparum CQR transporter gene.