Roger Le Grand

TL;DR: In this paper, a two-component protein-based nanoparticle vaccine that displays multiple copies of the SARS-CoV-2 spike protein was proposed to curtail the severe acute respiratory syndrome coronavirus 2 pandemic.

TL;DR: An AAV-specific plasmapheresis column was developed which was shown to efficiently and selectively deplete anti-AAV antibodies without depleting the total immunoglobulin pool from plasma, providing proof-of-concept of a method for the A AV-specific depletion of neutralizing antibodies in the setting of in vivo gene transfer.

TL;DR: A deep impact of the timing between immunizations is revealed, and the importance of early but also late innate responses involving phenotypical changes, in shaping humoral immunity is highlighted.

TL;DR: By comprehensive multi-dimensional analysis of NK cells from secondary lymphoid organs, intestinal mucosa, liver, and blood, this work identified tissue- and species-specific patterns of NK cell frequencies, phenotypes, and potential activity during infection by the simian immunodeficiency virus.

TL;DR: This study identified key genes differentially methylated already in primary infection and in tissues that could contribute to the persisting metabolic disorders and inflammation in HIV-infected individuals despite effective treatment.