Roger Liang

TL;DR: It is demonstrated that 3-phosphoglycerate dehydrogenase (PHGDH), which catalyzes the rate-limiting step of glucose-derived serine synthesis, is a major determinant of brain metastasis in multiple human cancer types and preclinical models and suggests that PHGDH inhibitors may be useful in the treatment of head metastasis.

TL;DR: In this paper, the authors show that dietary fructose improves the survival of intestinal cells and increases intestinal villus length in several mouse models, which leads to an increase in gut surface area, enhanced absorption of lipids and the promotion of tumour growth and obesity.

TL;DR: In this article, the authors investigated the determinants of fructolytic ability and showed that GLUT5 is a robust and generalizable driver of fructose-dependent cell proliferation.

TL;DR: It is demonstrated that cell-intrinsic de novo serine synthesis is a major determinant of brain metastasis, and that PHGDH inhibitors may be useful in the treatment of patients with cancers that have spread to the brain.

TL;DR: In this paper, an evolutionary divergence in regulation of the glycolytic enzyme triosephosphate isomerase (TPI1) was found to be important in the development of lung adenocarcinoma.