S
S Al-Ali
Researcher at Newcastle University
Publications - 7
Citations - 347
S Al-Ali is an academic researcher from Newcastle University. The author has contributed to research in topics: Identification (biology) & microRNA. The author has an hindex of 5, co-authored 7 publications receiving 274 citations. Previous affiliations of S Al-Ali include University of Basrah.
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Journal ArticleDOI
A Transcriptional Signature of Fatigue Derived from Patients with Primary Sjögren's Syndrome
Katherine James,S Al-Ali,S Al-Ali,Jessica Tarn,Simon Cockell,Colin S. Gillespie,Victoria Hindmarsh,James Locke,Sheryl Mitchell,Dennis Lendrem,Simon J. Bowman,Elizabeth Price,Colin T. Pease,Paul Emery,Peter Lanyon,John Hunter,Monica Gupta,Michele Bombardieri,Nurhan Sutcliffe,Costantino Pitzalis,John McLaren,Annie Cooper,Marian Regan,Ian Giles,David A. Isenberg,Vadivelu Saravanan,David Coady,Bhaskar Dasgupta,Neil McHugh,Steven Young-Min,Robert J. Moots,N Gendi,Mohammed Akil,Bridget Griffiths,Anil Wipat,Julia L. Newton,Julia L. Newton,David Jones,John D. Isaacs,John D. Isaacs,Jennifer Hallinan,Wan-Fai Ng,Wan-Fai Ng +42 more
TL;DR: Systematic analysis of gene expression data from pSS patients discordant for fatigue identified 55 genes which are predictive of fatigue level using SVM classification, which represents the first step in understanding the underlying pathophysiological mechanisms of fatigue in patients with pSS.
Journal ArticleDOI
Systemic interferon type I and type II signatures in primary Sjögren's syndrome reveal differences in biological disease activity
Iris L A Bodewes,S Al-Ali,S Al-Ali,Cornelia G van Helden-Meeuwsen,Naomi I Maria,Jessica Tarn,Dennis Lendrem,Marco W.J. Schreurs,Eline C. Steenwijk,Paul L A van Daele,Tim Both,Simon J. Bowman,Bridget Griffiths,Wan-Fai Ng,Wan-Fai Ng,UK primary Sjögren’s syndrome registry,Marjan A. Versnel +16 more
TL;DR: The data raise the possibility that the ESSDAI biological domain score may be a more sensitive endpoint for trials targeting either IFN pathway.
Journal ArticleDOI
Symptom-based stratification of patients with primary Sjögren’s syndrome: multi-dimensional characterisation of international observational cohorts and reanalyses of randomised clinical trials
Tarn,Nadia Howard-Tripp,Nadia Howard-Tripp,Dennis Lendrem,Xavier Mariette,A Saraux,Devauchelle-Pensec,Raphaèle Seror,Andrew J. Skelton,Katherine James,Peter McMeekin,S Al-Ali,S Al-Ali,Katie Hackett,Katie Hackett,BC Lendrem,Ben Hargreaves,Ben Hargreaves,John Casement,Sheryl Mitchell,Simon J. Bowman,Elizabeth Price,Colin T. Pease,Paul Emery,Peter Lanyon,John Hunter,Monisha Gupta,Michele Bombardieri,Nurhan Sutcliffe,Costantino Pitzalis,John McLaren,Annie Cooper,M Regan,Ian Giles,David A. Isenberg,Saravanan,David Coady,Bhaskar Dasgupta,Neil McHugh,Steven Young-Min,Robert J. Moots,N Gendi,M Akil,Bridget Griffiths,Sja Johnsen,KB Norheim,R Omdal,Deborah Stocken,Colin C Everett,Catherine Fernandez,John D. Isaacs,John D. Isaacs,J.-E. Gottenberg,J.-E. Gottenberg,Wan-Fai Ng,Wan-Fai Ng,French, Assess, cohort,Uk, Primary, Sjogren's, Syndrome, Registry +57 more
TL;DR: A robust method for stratification on the basis of patient-reported symptoms of patients with primary Sjögren's syndrome revealed distinct pathobiological endotypes with distinct responses to immunomodulatory treatments.
Journal ArticleDOI
Clinically proven mtDNA mutations are not common in those with chronic fatigue syndrome.
Elizna M. Schoeman,Francois H. van der Westhuizen,Elardus Erasmus,Etresia van Dyk,Charlotte V. Y. Knowles,S Al-Ali,S Al-Ali,Wan-Fai Ng,Wan-Fai Ng,Robert W. Taylor,Julia L. Newton,Julia L. Newton,Joanna L. Elson,Joanna L. Elson +13 more
TL;DR: The work supports the assertion that CFS should not be considered to fall within the spectrum of mt DNA disease, however, the current study cannot exclude a role for nuclear genes with a mitochondrial function, nor a role of mtDNA population variants in susceptibility to disease.
Journal ArticleDOI
Identification of Whole Blood Gene Expression Signature in Primary Sjogren's Syndrome Associated Lymphoma
S Al-Ali,Andrew J. Skelton,Simon Cockell,Jessica Tarn,Katherine James,Simon J. Bowman,B Griffiths,James Locke,D Young,Wan-Fai Ng,Ukpssr +10 more
TL;DR: The aim of the project is to provide a database of whole blood gene expression signatures in primary Sjögren’s Syndrome to help understand the pathogenesis and treatment of pSS-associated lymphoma.